N-Ethyl-(2-thienylmethyl)amine

Base Information

• Chemical Name: N-Ethyl-(2-thienylmethyl)amine
• CAS No.: 58255-25-7
• Molecular Formula: C7H11NS
• Molecular Weight: 141.237
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60405875
• Wikidata: Q82210605
• Mol file: 58255-25-7.mol

Synonyms:N-Ethyl-(2-thienylmethyl)amine;58255-25-7;N-(thiophen-2-ylmethyl)ethanamine;2-Thiophenemethanamine, N-ethyl-;ethyl[(thiophen-2-yl)methyl]amine;MFCD04478205;N-(thien-2-ylmethyl)ethanamine;N-(2-Thienylmethyl)ethanamine;N-Ethyl-2-thienylamine;SCHEMBL2719543;DTXSID60405875;LZRQTSDHULJXBN-UHFFFAOYSA-N;HMS1780J20;N-ethyl-N-(2-thienylmethyl)amine;STK524234;N-[(Thiophen-2-yl)methyl]ethanamine;AKOS000201467;AS-31184;SY002526;N-(thien-2-ylmethyl)ethanamine, AldrichCPR;CS-0453885;EN300-12769;A869493

Chemical Property of N-Ethyl-(2-thienylmethyl)amine

Chemical Property:

• Vapor Pressure: 0.509mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 191.6 °C at 760 mmHg
• PKA: 9.23±0.10(Predicted)
• Flash Point: 69.7 °C
• PSA: 40.27000
• Density: 1.03 g/cm³
• LogP: 2.24850
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 141.06122053
• Heavy Atom Count: 9
• Complexity: 75.3

Purity/Quality:

98%min ^*data from raw suppliers

N-Ethyl-(2-thienylmethyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC1=CC=CS1

Technology Process of N-Ethyl-(2-thienylmethyl)amine

There total 4 articles about N-Ethyl-(2-thienylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-ethylthiophene-2-carboxamide (98547-26-3) → N-ethyl-N-thenylamine (58255-25-7)

Guidance literature:

N-ethylthiophene-2-carboxamide; With bis(cyclopentadienyl)dihydrozirconium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; at 20 ℃; Glovebox; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; for 2h; Glovebox; Inert atmosphere;

DOI:10.1016/S1872-2067(21)63853-6

Reference yield: 77.0%

thiophene-2-carbaldehyde (98-03-3) + ethanamine hydrochloride (557-66-4) → N-ethyl-N-thenylamine (58255-25-7)

Guidance literature:

thiophene-2-carbaldehyde; ethanamine hydrochloride; With triethylamine; In methanol; at 0 ℃; for 0.5h;

With methanol; sodium tris(acetoxy)borohydride; at 0 - 20 ℃;

Reference yield: 60.0%

thiophene-2-carbaldehyde (98-03-3) + ethylamine (75-04-7,85404-22-4) → N-ethyl-N-thenylamine (58255-25-7)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃;

DOI:10.1021/jo050368k

upstream raw materials:

N-ethylthiophene-2-carboxamide

thiophene-2-carbaldehyde

ethylamine

ethanamine hydrochloride

Downstream raw materials:

N-ethyl-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide

N-ethyl-2-phenoxy-N-(thiophen-2-ylmethyl)acetamide

N-ethyl-N-(thiophen-2-ylmethyl)-2-(o-tolyloxy)acetamide

N-ethyl-N-(thiophen-2-ylmethyl)-2-(m-tolyloxy)acetamide

Refernces

• 1、 -. "COMPOUNDS USEFUL AS MODULATORS OF TRPM8". Page/Page column 62; 63. . Retrieved 2012/05/20.