2,4-DICHLOROBENZHYDRAZIDE

Base Information

• Chemical Name: 2,4-DICHLOROBENZHYDRAZIDE
• CAS No.: 5814-06-2
• Molecular Formula: C7H6Cl2N2O
• Molecular Weight: 205.043
• Hs Code.: 2928000090
• Mol file: 5814-06-2.mol

Synonyms:2,4-Dichlorobenzoic acid hydrazide;NSC 150855;

Chemical Property of 2,4-DICHLOROBENZHYDRAZIDE

Chemical Property:

• Melting Point: 168-170 °C
• Refractive Index: 1.605
• PSA: 55.12000
• Density: 1.455 g/cm³
• LogP: 2.68810

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichlorobenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DICHLOROBENZHYDRAZIDE

There total 7 articles about 2,4-DICHLOROBENZHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2,4-dichlorobenzoate (35112-28-8) → 2,4-dichlorobenzohydrazide (5814-06-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 22h; Reflux;

DOI:10.1021/acs.jmedchem.5b00608

Reference yield: 83.0%

2,4 dichlorobenzoic acid (50-84-0) → 2,4-dichlorobenzohydrazide (5814-06-2)

Guidance literature:

With hydrazine hydrate; for 0.0416667h; Microwave irradiation;

Reference yield: 68.0%

ethyl 2,4-dichlorobenzoate (56882-52-1) → 2,4-dichlorobenzohydrazide (5814-06-2)

Guidance literature:

With hydrazine hydrate; Reflux; Alcoholic solution;

DOI:10.1016/j.ejmech.2010.05.049

upstream raw materials:

methyl 2,4-dichlorobenzoate

ethyl 2,4-dichlorobenzoate

2,4 dichlorobenzoic acid

2,4-dichlorobenzoyl chloride

Downstream raw materials:

5-nitro-furfural-(2,4-dichloro-benzoylhydrazone)

2,4-Dichloro-benzoic acid [1-furan-2-yl-meth-(E)-ylidene]-hydrazide

2,4-Dichloro-benzoic acid pent-(E)-ylidene-hydrazide

2-(3,4-Dichloro-phenyl)-5-(2,4-dichloro-phenyl)-[1,3,4]oxadiazole

Refernces

• 1、 Lin, Lin,Lin, Guangyao,Zhou, Qingtong,Bathgate, Ross A.D.,Gong, Grace Qun,Yang, Dehua,Liu, Qing,Wang, Ming-Wei. "Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists". supporting information. . Retrieved 2021/03/16.
• 2、 Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun. "Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles". . p. 11572 - 11581. Retrieved 2021/10/12.