Paromamine

Base Information

• Chemical Name: Paromamine
• CAS No.: 534-47-4
• Molecular Formula: C12H25 N3 O7
• Molecular Weight: 323.346
• UNII: WGK534PM7Q
• DSSTox Substance ID: DTXSID20968057
• Nikkaji Number: J92.781C
• Wikidata: Q27107621
• Metabolomics Workbench ID: 53346
• ChEMBL ID: CHEMBL606552
• Mol file: 534-47-4.mol

Synonyms:paromamine

Chemical Property of Paromamine

Chemical Property:

• Vapor Pressure: 1.46E-16mmHg at 25°C
• Boiling Point: 593.6°Cat760mmHg
• Flash Point: 312.8°C
• PSA: 197.67000
• Density: 1.56g/cm³
• LogP: -2.98110
• XLogP3: -5.1
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 3
• Exact Mass: 323.16925015
• Heavy Atom Count: 22
• Complexity: 377

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)O)O)N
• Isomeric SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O)O)N

Technology Process of Paromamine

There total 18 articles about Paromamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

paromomycin sulfate (7205-49-4) → Paromamine (534-47-4,11030-86-7)

Guidance literature:

With acetyl chloride; In methanol; at 0 - 70 ℃; for 4.41667h;

Reference yield: 65.0%

paromomycin (7542-37-2,1390-73-4) → Paromamine (534-47-4,11030-86-7)

Guidance literature:

With hydrogenchloride; In methanol; at 70 ℃; for 10h;

DOI:10.1016/S0040-4039(00)00586-4

Reference yield:

(1S,2R,3R,4S,6R)-4,6-Diamino-3-((2S,3R,4R,5S,6R)-3-amino-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-cyclohexane-1,2-diol → Paromamine (534-47-4,11030-86-7)

Guidance literature:

With hydrogen; palladium dihydroxide; In water; acetic acid; for 21h; under 760 Torr; Ambient temperature;

DOI:10.1021/ja9910356

upstream raw materials:

paromomycin hydrochloride

paromomycin sulfate

paromomycin

2-deoxystreptamine

Downstream raw materials:

γ-L-Glu-[(S)-4-amino-2-hydroxybutyryl]-paromamine

Refernces

• 1、 -. "Novel aminoglycosides and uses thereof in the treatment of genetic disorders". Page/Page column 25-26. . Retrieved 2009/04/24.
• 2、 -. "NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS". Page/Page column 58-59. . Retrieved 2008/06/13.