4-aminocyclohexan-1-ol

Base Information

• Chemical Name: 4-aminocyclohexan-1-ol
• CAS No.: 56239-26-0
• Molecular Formula: C6H13NO^.HCl
• Molecular Weight: 151.636
• Hs Code.: 2922199090
• Mol file: 56239-26-0.mol

Synonyms:Cyclohexanol,4-amino-, hydrochloride, cis- (9CI);cis-4-Aminocyclohexanol hydrochloride;cis-4-Hydroxycyclohexylamine hydrochloride;

Chemical Property of 4-aminocyclohexan-1-ol

Chemical Property:

• Melting Point: 225-227 °C
• Boiling Point: 241.2 °C at 760 mmHg
• Flash Point: 99.7 °C
• PSA: 46.25000
• Density: 1.037g/cm3
• LogP: 1.75090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-4-AminocyclohexanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi:
• Statements: 36/37/38:
• Safety Statements: R26;R37/39:

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-aminocyclohexan-1-ol is used in the preparation of potential hypertensive agents and other biologically active compounds.

Technology Process of 4-aminocyclohexan-1-ol

There total 1 articles about 4-aminocyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride (56239-25-9) → (1s,4s)-4-aminocyclohexan-1-ol hydrochloride (56239-26-0)

Guidance literature:

(+/-)-2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride; With hydrogen; platinum(IV) oxide; for 7h; under 1500.15 Torr;

With hydrogenchloride; In 1,4-dioxane;

Reference yield: 96.26%

di-tert-butyl dicarbonate (24424-99-5) + (1s,4s)-4-aminocyclohexan-1-ol hydrochloride (56239-26-0) → cis-(4-hydroxycyclohexyl)carbamic acid tert-butyl ester (167081-25-6)

Guidance literature:

With triethylamine; In dichloromethane; at 21 ℃; for 16h;

Reference yield: 88.0%

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + (1s,4s)-4-aminocyclohexan-1-ol hydrochloride (56239-26-0) → (1r,4r)-4-(morpholin-4-yl)cyclohexan-1-ol (1228947-14-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b01290

upstream raw materials:

(+/-)-2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride

Downstream raw materials:

6-(4-amino-cis-cyclohexyloxy)-7-benzylsulfanyl-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

cis-4-(2-(4-(trifluoromethyl)phenylamino)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamino)cyclohexanol

2-(cis-4-hydroxycyclohexyl)isoindoline-1,3-dione

4-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-cyclohexanol

Refernces