SODIUM 2-HYDROXYBUTYRATE

Base Information

• Chemical Name: SODIUM 2-HYDROXYBUTYRATE
• CAS No.: 5094-24-6
• Molecular Formula: C4H7NaO3
• Molecular Weight: 126.088
• Mol file: 5094-24-6.mol

Synonyms:Butanoicacid, 2-hydroxy-, monosodium salt (9CI);Butyric acid, 2-hydroxy-, monosodiumsalt (8CI);2-Hydroxybutanoic acid sodium salt;2-Hydroxybutyric acid sodiumsalt;Butanoic acid, 2-hydroxy-, monosodium salt, (?à)-;Butyric acid, 2-hydroxy-, monosodium salt, DL-;DL-a-Hydroxybutyric acid sodium salt;Sodium (DL)-a-hydroxybutyrate;Sodium (?à)-2-hydroxybutyrate;Sodium2-hydroxybutanoate;Sodium 2-hydroxybutyrate;Sodium a-hydroxybutyrate;

Chemical Property of SODIUM 2-HYDROXYBUTYRATE

Chemical Property:

• Vapor Pressure: 0.00759mmHg at 25°C
• Melting Point: 133-135 °C(lit.)
• Boiling Point: 238.3 °C at 760 mmHg
• Flash Point: 112.2 °C
• PSA: 60.36000
• Density: 1.195g/cm3
• LogP: -1.49280
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: almost transparency

Purity/Quality:

98%,99%, ^*data from raw suppliers

Sodium2-Hydroxybutyrate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium 2-Hydroxybutyrate is used to prepare (D)-β-Hydroxybutyrate, which inhibits adipocyte lipolysis, in a pharmacological study.

Technology Process of SODIUM 2-HYDROXYBUTYRATE

There total 2 articles about SODIUM 2-HYDROXYBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S)-2-hydroxybutanoic acid (3347-90-8) → (S)-2-hydroxybutyric acid sodium salt (5094-24-6,19054-57-0)

Guidance literature:

With sodium methylate; In methanol; for 0.5h; Cooling with ice;

Reference yield:

2-oxobutyric acid, sodium salt (2013-26-5) → (R)-2-hydroxy-butyric acid ; sodium-salt (5094-24-6,19054-57-0)

Guidance literature:

With 1,4-dihydronicotinamide adenine dinucleotide; tris hydrochloride; In water; at 30 ℃; pH=7.5; Enzyme kinetics;

DOI:10.1271/bbb.70827

Reference yield: 79.0%

(S)-2-hydroxybutyric acid sodium salt (5094-24-6,19054-57-0) + butan-1-ol (71-36-3) → n-butyl (S)-2-hydroxybutanoate (132513-51-0)

Guidance literature:

With sulfuric acid; at 110 ℃; for 1.5h;

upstream raw materials:

2-oxobutyric acid, sodium salt

(2S)-2-hydroxybutanoic acid

Downstream raw materials:

2-Benzyloxy-butyric acid benzyl ester

Benzyl 2-hydroxybutanoate

2-Hydroxybutanoic acid

triethyl 2-oxa-1,3,3-butanetricarboxylate

Refernces

• 1、 Wada, Yusuke,Iwai, Saho,Tamura, Yusuke,Ando, Tomonori,Shinoda, Takeshi,Arai, Kazuhito,Taguchi, Hayao. "A new family of D-2-hydroxyacid dehydrogenases that comprises D-mandelate dehydrogenases and 2-ketopantoate reductases". . p. 1087 - 1094. Retrieved 2008/09/21.