Diethyl meso-2,5-dibromoadipate

Base Information

• Chemical Name: Diethyl meso-2,5-dibromoadipate
• CAS No.: 54221-37-3
• Molecular Formula: C10H16Br2O4
• Molecular Weight: 360.043
• Hs Code.: 2917190090
• Mol file: 54221-37-3.mol

Synonyms:diethyl (2R,5S)-2,5-dibromohexanedioate;

Chemical Property of Diethyl meso-2,5-dibromoadipate

Chemical Property:

• Melting Point: 65-66 °C
• Boiling Point: 338.6 °C at 760 mmHg
• Flash Point: 158.6 °C
• PSA: 52.60000
• Density: 1.581 g/cm³
• LogP: 2.41980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

90%,98% ^*data from raw suppliers

Diethyl meso-2,5-dibromoadipate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl meso-2,5-dibromoadipate

There total 9 articles about Diethyl meso-2,5-dibromoadipate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethanol (64-17-5) + 2,5-dibromohexanedioyl dichloride (29548-86-5,137300-49-3) → meso-Diethyl 2,5-Dibromoadipate (54221-37-3)

Guidance literature:

for 16h; Ambient temperature;

DOI:10.1021/jo00296a071

Reference yield:

Adipic acid (124-04-9) → diethyl meso-2,5-dibromoadipate (54221-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: SO₂Cl₂ / 2.5 h / 65 - 70 °C

2: Br₂ / 85 - 90 °C / Irradiation

With sulfuryl dichloride; bromine;

DOI:10.1021/ja983047h

Reference yield:

Adipic acid dichloride (111-50-2) → diethyl meso-2,5-dibromoadipate (54221-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / 85 - 90 °C / Irradiation

With bromine;

DOI:10.1021/ja983047h

upstream raw materials:

Adipic acid dichloride

Adipic acid

ethanol

(2R,5S)-2,5-Dibromo-hexanedioyl dichloride

Downstream raw materials:

ethyl piperidine-1-propionate

N-isopropyl-N-methyl-β-alanine ethyl ester

cis-tetrahydrofuran-2,5-dicarboxylic acid

ethyl 3-(dipropylamino)propanoate

Refernces

• 1、 Fraenkel, Gideon,Duncan, Joseph H.,Wang, Jinhai. "Restricted stereochemistry of solvation of allylic lithium compounds: Structural and dynamic consequences". . p. 432 - 443. Retrieved 2007/10/03.