4-METHYL-5-ACETYL THIAZOLE

Base Information

• Chemical Name: 4-METHYL-5-ACETYL THIAZOLE
• CAS No.: 38205-55-9
• Molecular Formula: C6H7NOS
• Molecular Weight: 141.194
• Hs Code.: 2934100090
• Mol file: 38205-55-9.mol

Synonyms:Ketone,methyl 4-methyl-5-thiazolyl (7CI);5-Acetyl-4-methylthiazole;

Chemical Property of 4-METHYL-5-ACETYL THIAZOLE

Chemical Property:

• Vapor Pressure: 0.073mmHg at 25°C
• Melting Point: 28-29 °C
• Refractive Index: 1.539
• Boiling Point: 228.6 °C at 760 mmHg
• PKA: 1.25±0.10(Predicted)
• Flash Point: 92 °C
• PSA: 58.20000
• Density: 1.177 g/cm³
• LogP: 1.65410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

1-(4-Methyl-1,3-thiazol-5-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-5-ACETYL THIAZOLE

There total 8 articles about 4-METHYL-5-ACETYL THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiocarboxamide (115-08-2) + 3-bromopentane-2,4-dione (3043-28-5) → 1-(4-methyl-thiazol-5-yl)-ethanone (38205-55-9)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 2.5h; Reflux;

Reference yield:

thiocarboxamide (115-08-2) + 3-chloropentane-2,4-dione (1694-29-7) → 1-(4-methyl-thiazol-5-yl)-ethanone (38205-55-9)

Guidance literature:

With pyridine; ethanol;

DOI:10.1021/ja01219a012

Reference yield:

5-acetyl-4-methylthiazole-2-amine (30748-47-1) + isopentyl nitrite (110-46-3) → 1-(4-methyl-thiazol-5-yl)-ethanone (38205-55-9)

Guidance literature:

In tetrahydrofuran; N-methyl-acetamide; di-isopropyl ether; water; ethyl acetate;

upstream raw materials:

formamide

3-chloropentane-2,4-dione

ethanol

thiocarboxamide

Downstream raw materials:

2-bromo-1-(4-methylthiazol-5-yl)ethanone hydrobromide

5-hydroxyethyl-4-methylthiazole

Refernces

• 1、 -. "5 - (3 - Phenyl-acryloyl) thiazole derivative and its preparation method and application (by machine translation)". . . Retrieved 2018/10/02.