1-chloro-3-fluoro-propan-2-one

Base Information

• Chemical Name: 1-chloro-3-fluoro-propan-2-one
• CAS No.: 453-12-3
• Molecular Formula: C3H4 Cl F O
• Molecular Weight: 110.51
• Hs Code.: 2914700090
• Mol file: 453-12-3.mol

Synonyms:1-Chloro-3-fluoroacetone;1-Fluoro-3-chloro-2-propanone; 1-Fluoro-3-chloroacetone; NSC 21300

Chemical Property of 1-chloro-3-fluoro-propan-2-one

Chemical Property:

• Vapor Pressure: 16.2mmHg at 25°C
• Boiling Point: 119.1°Cat760mmHg
• Flash Point: 25.9°C
• PSA: 17.07000
• Density: 1.201g/cm³
• LogP: 0.76380

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-chloro-3-fluoro-propan-2-one

There total 4 articles about 1-chloro-3-fluoro-propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-chloro-3-fluoroisopropanol (146580-24-7,453-11-2) → 1-Chloro-3-fluoro-prop-2-one (453-12-3)

Guidance literature:

With Jones reagent; at 60 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.07.013

Reference yield:

1-fluoro-2-propanone (430-51-3) → 1-Chloro-3-fluoro-prop-2-one (453-12-3)

Guidance literature:

With chlorine;

DOI:10.1039/j39710000279

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-chloroacetyl fluoride (359-14-8) → 1-Chloro-3-fluoro-prop-2-one (453-12-3)

Guidance literature:

With diethyl ether; hydrogen fluoride;

upstream raw materials:

diazomethane

2-chloroacetyl fluoride

1-chloro-3-fluoroisopropanol

1-fluoro-2-propanone

Downstream raw materials:

N-(4-fluoromethyl-thiazol-2-yl)-acetamide

1-Acetoxy-3-fluorpropen-2-on

(1-fluoroacetonyl)-triphenylphosphonium chloride

2-chloromethyl-2-fluoromethyl-[1,3]dioxolane

Refernces

• 1、 Borz?cka, Wioleta,Lavandera, Iván,Gotor, Vicente. "Biocatalyzed synthesis of both enantiopure fluoromisonidazole antipodes". supporting information. p. 5022 - 5025. Retrieved 2013/09/02.