Lanicemine

Base Information

• Chemical Name: Lanicemine
• CAS No.: 153322-05-5
• Deprecated CAS: 301643-63-0
• Molecular Formula: C13H14 N2
• Molecular Weight: 198.2637
• UNII: 9TMU325RK3
• DSSTox Substance ID: DTXSID30870011
• Nikkaji Number: J704.990K
• Wikipedia: Lanicemine
• Wikidata: Q15409412
• NCI Thesaurus Code: C77601
• Metabolomics Workbench ID: 152972
• ChEMBL ID: CHEMBL467084
• Mol file: 153322-05-5.mol

Synonyms:AZD6765;lanicemine

Chemical Property of Lanicemine

Chemical Property:

• Vapor Pressure: 0.000712mmHg at 25°C
• Boiling Point: 307.7°Cat760mmHg
• PKA: 8.29±0.10(Predicted)
• Flash Point: 160.5°C
• PSA: 38.91000
• Density: 1.097g/cm³
• LogP: 3.02440
• Solubility.: ≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 198.115698455
• Heavy Atom Count: 15
• Complexity: 175

Purity/Quality:

99%, ^*data from raw suppliers

Lanicemine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CC2=CC=CC=N2)N
• Isomeric SMILES: C1=CC=C(C=C1)[C@H](CC2=CC=CC=N2)N
• Recent ClinicalTrials: NMDA Receptor Modulation for Hyperarousal in PTSD
• Recent EU Clinical Trials: A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled, Phase IIb Efficacy and Safety Study of Adjunctive AZD6765 in Patients with Major Depressive Disorder (MDD) and a History of Inadequate Response to Antidepressants.
• Description: Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 μM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 μM. Compared to ketamine , lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.
• Uses: Lanicemine is a non-selective voltage-dependant NMDA channel blocker. It is a potential anti-depressant which does not cause psychotomimetic activity. Potential anti-hypertensive agent.