Propanedioic acid, diethyl ester, ion(1-), sodium

Base Information

• Chemical Name: Propanedioic acid, diethyl ester, ion(1-), sodium
• CAS No.: 996-82-7
• Molecular Formula: C7H11O4.Na
• Molecular Weight: 182.152
• Mol file: 996-82-7.mol

Synonyms:

Chemical Property of Propanedioic acid, diethyl ester, ion(1-), sodium

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, diethyl ester, ion(1-), sodium

There total 3 articles about Propanedioic acid, diethyl ester, ion(1-), sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl 2-bromomalonate (685-87-0) → sodium diethylmalonate (996-82-7,34727-00-9,73177-21-6) + diethyl dibromomalonate (631-22-1) + C7H10BrNaO4

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 3 - 6 ℃; Inert atmosphere;

DOI:10.1016/j.jfluchem.2021.109864

Reference yield:

diethyl 2-chloromalonate (14064-10-9) + C7H10ClNaO4 → sodium diethylmalonate (996-82-7,34727-00-9,73177-21-6) + diethyl dichloromalonate (20165-81-5)

Guidance literature:

at 0 ℃; Inert atmosphere;

DOI:10.1016/j.jfluchem.2021.109864

Reference yield:

(E)-3,7-dimethyl-2,6-octadien-1-ylcarbonic acid ethyl ester (61573-91-9) + diethyl malonate (105-53-3) → sodium diethylmalonate (996-82-7,34727-00-9,73177-21-6) + diethyl [(2E)-3,7-dimethylocta-2,6-dienyl]malonate (19894-79-2) + 2-(1,5-Dimethyl-1-vinyl-hex-4-enyl)-malonic acid diethyl ester (99372-02-8)

Guidance literature:

tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; at 50 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1007/BF00695820

upstream raw materials:

(E)-3,7-dimethyl-2,6-octadien-1-ylcarbonic acid ethyl ester

diethyl malonate

diethyl 2-chloromalonate

Diethyl 2-bromomalonate

Downstream raw materials:

epoxybutene

Diethyl methylmalonate

butane-1,1,2,3-tetracarboxylic acid tetraethyl ester

tetraethyl ethane-1,1,2,2-tetracarboxylate

Refernces

• 1、 Petrushkina, E. A.,Zakharkin, L. I.. "Neryl- and geranyltriethylammonium halides in the allylation of sodium diethyl malonate. The effect of the leaving group of the allylating reagent on the selectivity of the reaction". . p. 249 - 251. Retrieved 2007/10/02.