6-Bromo-2-phenyl-1H-quinazolin-4-one

Base Information

• Chemical Name: 6-Bromo-2-phenyl-1H-quinazolin-4-one
• CAS No.: 27398-50-1
• Molecular Formula: C14H9BrN2O
• Molecular Weight: 301.142
• Hs Code.: 2933990090
• Mol file: 27398-50-1.mol

Synonyms:6-Bromo-2-phenylquinazolin-4(3H)-one;

Chemical Property of 6-Bromo-2-phenyl-1H-quinazolin-4-one

Chemical Property:

• Melting Point: 303-305 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 455.5±47.0 °C(Predicted)
• PKA: 6.08±0.20(Predicted)
• PSA: 46.01000
• Density: 1.57 g/cm³
• LogP: 3.76490

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Bromo-2-phenyl-1H-quinazolin-4-one

There total 40 articles about 6-Bromo-2-phenyl-1H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzimidamide hydrochloride + 5-bromo-2-aminobenzoic acid hexafluoroisopropanol ester → 6-bromo-2-phenyl-3H,4H-quinazolin-4-one (27398-50-1)

Guidance literature:

With potassium phosphate; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Green chemistry;

Reference yield: 97.0%

benzamidine monohydrochloride (1670-14-0) + 5-bromo-2-aminobenzoic acid hexafluoroisopropanol ester → 6-bromo-2-phenyl-3H,4H-quinazolin-4-one (27398-50-1)

Guidance literature:

With potassium phosphate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1039/d1ra00324k

Reference yield: 93.0%

2-amino-5-bromo-N-methoxybenzamide (40928-18-5) + benzaldehyde (100-52-7) → 6-bromo-2-phenyl-3H,4H-quinazolin-4-one (27398-50-1)

Guidance literature:

With acetic acid; at 100 ℃; for 0.3h;

DOI:10.1039/c4ra04331f

upstream raw materials:

2-benzamido-5-bromobenzamide

N-(4-bromo-2-cyanophenyl)benzamide

6-bromo-2-phenyl-4H-benzo[2,3-d]-1,3-oxazin-4-one

5-bromo-2-iodo-benzoic acid

Downstream raw materials:

6-bromo-4-chloro-2-phenyl-quinazoline

[(6-bromo-2-phenyl-4-quinazolinyl)oxy]-acetyl hydrazine

C₂₀H₁₅BrN₄O₃

6-bromo-4-(1,3,4-oxadiazol-2-ylmethoxy)-2-phenylquinazoline

Refernces

• 1、 Hou, Huiqing,Ma, Xinhua,Lin, Yingying,Lin, Jin,Sun, Weiming,Wang, Lei,Xu, Xiuzhi,Ke, Fang. "Electrochemical synthesis of quinazolinone: via I2-catalyzed tandem oxidation in aqueous solution". . p. 17721 - 17726. Retrieved 2021/05/29.
• 2、 Yang, Li,Hou, Huiqing,Li, Lan,Wang, Jin,Zhou, Sunying,Wu, Mei,Ke, Fang. "Electrochemically induced synthesis of quinazolinonesviacathode hydration ofo-aminobenzonitriles in aqueous solutions". supporting information. p. 998 - 1003. Retrieved 2021/02/16.