2-AMINOMETHYL-4-METHYL-PENTANOIC ACID

Base Information

• Chemical Name: 2-AMINOMETHYL-4-METHYL-PENTANOIC ACID
• CAS No.: 100869-07-6
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.2
• Mol file: 100869-07-6.mol

Synonyms:2-(Aminomethyl)-4-methylpentanoic acid;

Chemical Property of 2-AMINOMETHYL-4-METHYL-PENTANOIC ACID

Chemical Property:

• Boiling Point: 249.115 °C at 760 mmHg
• PKA: 3.51±0.21(Predicted)
• Flash Point: 104.461 °C
• PSA: 63.32000
• Density: 1.014 g/cm³
• LogP: 1.39230

Purity/Quality:

99% ^*data from raw suppliers

2-(Aminomethyl)-4-methyl-pentanoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINOMETHYL-4-METHYL-PENTANOIC ACID

There total 1 articles about 2-AMINOMETHYL-4-METHYL-PENTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyano-4-methyl-pent-2-enoic acid (760-58-7) → 2-cyano-4-methylpentanoic acid (18283-41-5) + 2-(aminomethyl)-4-methylpentanoic acid (100869-07-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; Overall yield = ~ 90 %;

DOI:10.1021/op4002774

Reference yield:

2-(aminomethyl)-4-methylpentanoic acid (100869-07-6) + benzoyl chloride (98-88-4) → 2-(benzamidomethyl)-4-methylpentanoic acid

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 20 ℃; for 4h;

DOI:10.1021/jacs.1c00249

Reference yield:

2-(aminomethyl)-4-methylpentanoic acid (100869-07-6) + (R)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)-2-methylpyrrolidin-2-ylcarboxamide + nickel diacetate (373-02-4,14998-37-9,33025-09-1,94044-50-5,98268-31-6) → C28H34ClN3NiO3 + C28H34ClN3NiO3

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; at 80 ℃; for 96h; Overall yield = 80 %; Overall yield = 44.3 mg;

DOI:10.1021/acs.joc.8b01336

upstream raw materials:

2-cyano-4-methyl-pent-2-enoic acid

Downstream raw materials:

2-((tert-butoxycarbonylamino)methyl)-4-methylpentanoic acid

Refernces