2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

• Chemical Name: 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS No.: 1204333-58-3
• Molecular Formula: C₁₁H₁₄BF₂NO₂
• Molecular Weight: 241.045
• Hs Code.: 2934999090
• Mol file: 1204333-58-3.mol

Synonyms:2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;(2,6-Difluoro-4-pyridyl)-(2-hydroxy-1,1,2-trimethyl-propoxy)borinic acid;2,6-Difluoropyridine-4-boronic acid, pinacol ester;

Chemical Property of 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Boiling Point: 363.89 °C at 760 mmHg
• PKA: -6.91±0.10(Predicted)
• Flash Point: 173.875 °C
• PSA: 31.35000
• Density: 1.205 g/cm³
• LogP: 1.65900
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Difluoropyridine-4-boronic acid, pinacol ester

Technology Process of 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 3 articles about 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,6-difluoro pyridine (1513-65-1) + bis(pinacol)diborane (73183-34-3) → 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1204333-58-3)

Guidance literature:

1,10-Phenanthroline; chlorobis(cyclooctene)rhodium(I) dimer; In 1,2-dichloro-ethane; at 100 ℃; for 1h; Inert atmosphere;

Reference yield: 50.8%

2,6-difluoro pyridine (1513-65-1) + bis(pinacol)diborane (73183-34-3) → 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1204333-58-3) + 2,6-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1072945-00-6)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 100 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/acsmedchemlett.7b00258

Reference yield:

→ 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1204333-58-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

upstream raw materials:

2,6-difluoro pyridine

bis(pinacol)diborane

Downstream raw materials:

4‐bromo‐2,6‐difluoropyridine

Refernces

• 1、 -. "Nitrogen-containing heterocyclic compound and application thereof and organic electroluminescent device (by machine translation)". Paragraph 0077-0081; 0090-0095. . Retrieved 2019/11/25.
• 2、 -. "SERINE/THREONINE KINASE INHIBITORS". Paragraph 00188. . Retrieved 2015/06/18.