(+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE

Base Information

• Chemical Name: (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE
• CAS No.: 82830-44-2
• Molecular Formula: C₁₁H₁₆INO₂*ClH
• Molecular Weight: 357.619
• Mol file: 82830-44-2.mol

Synonyms:1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride; 2,5-Dimet

Chemical Property of (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE

Chemical Property:

• Melting Point: 200-202 °C
• PSA: 44.48000
• LogP: 3.70040
• Solubility.: H2O: 10 mg/mL

Purity/Quality:

98%Min ^*data from raw suppliers

DOI Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE

There total 4 articles about (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(+/-)-N-acetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (82830-50-0) → 4-iodo-2,5-dimethoxyphenylisopropylamine hydrochloride (42203-78-1,82830-44-2)

Guidance literature:

DOI:10.1021/jm00352a013

Reference yield:

(+/-)-N-acetyl-1-(2,5-dimethoxyphenyl)-2-aminopropane (42311-16-0) → 4-iodo-2,5-dimethoxyphenylisopropylamine hydrochloride (42203-78-1,82830-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.21 g / silver trifluoroacetate, I₂ / CHCl₃ / 18 h

2: 71 percent

With iodine; silver trifluoroacetate; In chloroform;

DOI:10.1021/jm00352a013

Reference yield:

N-[(R)-2-(2,5-Dimethoxy-phenyl)-1-methyl-ethyl]-acetamide → (-)-DOI hydrochloride (82830-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 31 percent / silver trifluoroacetate, I₂ / CHCl₃ / 18 h

2: 1.) NaOH

With sodium hydroxide; iodine; silver trifluoroacetate; In chloroform;

DOI:10.1021/jm00352a013

upstream raw materials:

(+/-)-N-acetyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

(+/-)-N-acetyl-1-(2,5-dimethoxyphenyl)-2-aminopropane

Refernces