2,2-Difluoropropionamide

Base Information

• Chemical Name: 2,2-Difluoropropionamide
• CAS No.: 49781-48-8
• Molecular Formula: C3H5F2NO
• Molecular Weight: 109.07
• Hs Code.: 2924199090
• Mol file: 49781-48-8.mol

Synonyms:2,2-DIFLUOROPROPIONAMIDE;2,2-Difluoropropionamide 97%;2,2-Difluoropropionamide97%;2,2-difluoropropanaMide

Chemical Property of 2,2-Difluoropropionamide

Chemical Property:

• Melting Point: 67
• Boiling Point: 212.4 °C at 760 mmHg
• Flash Point: 82.3 °C
• PSA: 43.09000
• Density: 1.214 g/cm³
• LogP: 0.82720

Purity/Quality:

97% ^*data from raw suppliers

2,2-Difluoropropionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Difluoropropionamide

There total 3 articles about 2,2-Difluoropropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.8%

2,2-difluoropropanoic acid (373-96-6) → 2,2-difluoropropionamide (49781-48-8)

Guidance literature:

With ammonia; In methanol; at 20 ℃; Inert atmosphere; Heating;

Reference yield: 49.0%

oxalyl dichloride (79-37-8) + 2,2-difluoropropanoic acid (373-96-6) → 2,2-difluoropropionamide (49781-48-8)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

→ 2,2-difluoropropionamide (49781-48-8)

Guidance literature:

Ester E(a), NH3;

upstream raw materials:

oxalyl dichloride

2,2-difluoropropanoic acid

Downstream raw materials:

2,2-difluoropropionitrile

Refernces

• 1、 -. "MEDICINAL COMPOSITIONS". . . Retrieved 2008/06/13.