(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl

Base Information

• Chemical Name: (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl
• CAS No.: 1006614-49-8
• Molecular Formula: C9H9F2N
• Molecular Weight: 169.1713
• Mol file: 1006614-49-8.mol

Synonyms:(1R trans)-2-(3, 4-Difluorophenyl)cyclopropane amine. HCl;

Chemical Property of (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl

Chemical Property:

• Boiling Point: 212.5 °C at 760 mmHg
• Flash Point: 99 °C
• PSA: 26.02000
• Density: 1.268 g/cm³
• LogP: 2.47970

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl

There total 87 articles about (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

(1R,2S)-2-(3,4-difluorophenyl)cyclopropane-1-carboxamide → (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (1006614-49-8,220352-38-5,1459719-81-3)

Guidance literature:

With sodium hypochlorite; sodium hydroxide; In water; at 30 ℃; for 5h;

Reference yield: 95.0%

trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride (1402222-66-5,1156491-10-9) → (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (1006614-49-8,220352-38-5,1459719-81-3)

Guidance literature:

With sodium hydroxide; at 25 ℃; for 0.25h;

Reference yield: 94.7%

trans-N-(2-(3,4-difluorophenyl)cyclopropyl)trimethylacetamide → (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (1006614-49-8,220352-38-5,1459719-81-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

(1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide

(E)-3-(3,4-difluorophenyl)acrylic acid

trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

3,4-difluorocinnamoyl chloride

Downstream raw materials:

N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide

benzyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

benzyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

tert-butyl (5-amino-6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-2-(propylthio) pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate

Refernces

• 1、 -. "Preparation method of chiral aromatic cyclopropylamine and salt thereof and intermediate used in preparation method". Paragraph 0082-0084. . Retrieved 2020/06/20.
• 2、 -. "Synthetic method for ticagrelor intermediate (1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine". Paragraph 0046. . Retrieved 2018/07/30.