4-(2-NAPHTHYL)-4-OXOBUTANOICACID

Base Information

• Chemical Name: 4-(2-NAPHTHYL)-4-OXOBUTANOICACID
• CAS No.: 1590-22-3
• Molecular Formula: C14H12 O3
• Molecular Weight: 228.247
• Hs Code.: 2918300090
• Mol file: 1590-22-3.mol

Synonyms:Propionicacid, 3-(2-naphthoyl)- (6CI,7CI,8CI); 3-(2-Naphthoyl)propionic acid;4-(2-Naphthyl)-4-oxobutanoic acid; NSC 2081; NSC 404382; b-(2-Naphthoyl)propionic acid; g-Oxo-2-naphthalenebutanoic acid

Chemical Property of 4-(2-NAPHTHYL)-4-OXOBUTANOICACID

Chemical Property:

• Vapor Pressure: 3.04E-09mmHg at 25°C
• Melting Point: 174 °C
• Boiling Point: 459.6°C at 760 mmHg
• PKA: 4.53±0.17(Predicted)
• Flash Point: 245.9°C
• PSA: 54.37000
• Density: 1.249±0.06 g/cm3(Predicted)
• LogP: 2.88730

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Naphthoyl)propionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-(2-Naphthoyl)propionic Acid is an intermediate in the synthesis of 4-Phenanthrol (P295015), a metabolite of Phenanthrene.

Technology Process of 4-(2-NAPHTHYL)-4-OXOBUTANOICACID

There total 25 articles about 4-(2-NAPHTHYL)-4-OXOBUTANOICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C19H20O5 (1220638-77-6) → 4-(2-naphthyl)-4-oxobutyric acid (1590-22-3)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃;

Reference yield: 72.0%

succinic acid anhydride (108-30-5) + naphthalene (91-20-3,71998-51-1,72931-45-4) → 4-(2-naphthyl)-4-oxobutyric acid (1590-22-3)

Guidance literature:

With aluminium trichloride; at 20 ℃; for 0.3h;

DOI:10.1081/SCC-120023423

Reference yield: 60.0%

succinic acid anhydride (108-30-5) + naphthalene (91-20-3,71998-51-1,72931-45-4) → 4-(1-naphthyl)-4-oxobutanoic acid (4653-13-8) + 4-(2-naphthyl)-4-oxobutyric acid (1590-22-3)

Guidance literature:

In nitrobenzene;

DOI:10.1002/ardp.198700018

upstream raw materials:

succinic acid anhydride

naphthalene

2-naphthalenylmagnesium bromide

ethyl 3-(chloroformyl)propionate

Downstream raw materials:

γ-(2-naphthyl)-γ-butyrolactone

6-(β-napthyl)-2-(4-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-one

(S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]-4-(2-naphthyl)-4-oxobutanamide

4-(naphthalen-2-yl)butan-1-ol

Refernces

• 1、 Van Der Meijden, Maarten W.,Gelens, Edith,Quirs, Natalia Murillo,Fuhr, Javier D.,Gayone, J. Esteban,Ascolani, Hugo,Wurst, Klaus,Lingenfelder, Magal,Kellogg, Richard M.. "Synthesis, properties, and two-dimensional adsorption characteristics of 5-amino[6]hexahelicene". . p. 1484 - 1492. Retrieved 2016.
• 2、 Mogilaiah,Reddy, N. Vasudeva,Reddy, G. Randheer. "An efficient and novel method for the synthesis of β-aroylpropionic acids under solvent-free conditions". . p. 3109 - 3113. Retrieved 2003.
• 3、 Tran, Quan H.,Wang, Xiqu,Brookhart, Maurice,Daugulis, Olafs. "Cationic α-Diimine Nickel and Palladium Complexes Incorporating Phenanthrene Substituents: Highly Active Ethylene Polymerization Catalysts and Mechanistic Studies of syn/ anti Isomerization". . p. 4704 - 4716. Retrieved 2020.
• 4、 -. "Preparation method of light-driven molecular motor based on oxidized benzofuran structure". Paragraph 0015; 0072-0073. . Retrieved 2022/01/04.
• 5、 Bernhard, Yann,Gilbert, Joachim,Bousquet, Till,Favrelle-Huret, Audrey,Zinck, Philippe,Pellegrini, Sylvain,Pelinski, Lydie. "One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade". supporting information. p. 7870 - 7873. Retrieved 2019/12/24.