Pyrrolo[2,1-a]isoquinoline

Base Information

• Chemical Name: Pyrrolo[2,1-a]isoquinoline
• CAS No.: 234-92-4
• Molecular Formula: C12H9 N
• Molecular Weight: 167.21
• Hs Code.: 2933990090
• Mol file: 234-92-4.mol

Synonyms:Benz[g]indolizine;Benzopyrrocoline

Chemical Property of Pyrrolo[2,1-a]isoquinoline

Chemical Property:

• Melting Point: 83.5-84 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• PSA: 4.41000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 3.09250

Purity/Quality:

Pyrrolo[2,1-a]isoquinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[2,1-a]isoquinoline

There total 9 articles about Pyrrolo[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Methylthiopyrrolo<2,1-a>isoquinoline (102053-04-3) → pyrrolo[2,1-a]isoquinoline (234-92-4)

Guidance literature:

With nickel; In ethanol; for 10h; Heating;

Reference yield:

2,3,5,6-tetrahydropyrrolo[2,1-a]isoquinoline (853925-56-1) → pyrrolo[2,1-a]isoquinoline (234-92-4)

Guidance literature:

With palladium on activated charcoal; naphthalene; carbon dioxide;

DOI:10.1021/ja01111a022

Reference yield:

N-(2-phenylethyl)pyrrolidin-2-one (10135-23-6) → pyrrolo[2,1-a]isoquinoline (234-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus (V)-oxide; tetralin

2: palladium/charcoal; naphthalene; carbon dioxide

With palladium on activated charcoal; naphthalene; tetralin; carbon dioxide; phosphorus pentoxide;

DOI:10.1021/ja01111a022

upstream raw materials:

2,3,5,6-tetrahydropyrrolo[2,1-a]isoquinoline

2-Methylthiopyrrolo<2,1-a>isoquinoline

2-ethoxycarbonyl-methylisoquinolinium bromide

2-<1-ethoxycarbonyl-2,2-bis(methylthio)ethenyl>isoquinolinium iodide

Refernces