(2R,4S)-5,5,5-Trichloro-4-methyl-2-[methyl[(S)-4,4,4-trichloro-3-methyl-1-oxobutyl]amino]-N-[(S)-1-(2-thiazolyl)ethyl]pentanamide

Base Information Edit

Chemical Name:(2R,4S)-5,5,5-Trichloro-4-methyl-2-[methyl[(S)-4,4,4-trichloro-3-methyl-1-oxobutyl]amino]-N-[(S)-1-(2-thiazolyl)ethyl]pentanamide
CAS No.:67528-34-1
Molecular Formula:C₁₇H₂₃Cl₆N₃O₂S
Molecular Weight:546.173
Hs Code.:
Mol file:67528-34-1.mol

Synonyms:

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Chemical Property of (2R,4S)-5,5,5-Trichloro-4-methyl-2-[methyl[(S)-4,4,4-trichloro-3-methyl-1-oxobutyl]amino]-N-[(S)-1-(2-thiazolyl)ethyl]pentanamide Edit

Chemical Property:

Vapor Pressure:1.15E-15mmHg at 25°C
Boiling Point:627.6°Cat760mmHg
Flash Point:333.4°C
Density:1.423g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (2R,4S)-5,5,5-Trichloro-4-methyl-2-[methyl[(S)-4,4,4-trichloro-3-methyl-1-oxobutyl]amino]-N-[(S)-1-(2-thiazolyl)ethyl]pentanamide

There total 11 articles about (2R,4S)-5,5,5-Trichloro-4-methyl-2-[methyl[(S)-4,4,4-trichloro-3-methyl-1-oxobutyl]amino]-N-[(S)-1-(2-thiazolyl)ethyl]pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 623143-42-0
(1S)-1-(1,3-thiazol-2-yl)ethanamine

: 5,5,5-trichloro-4(S)-methyl-2(S)-[methyl(4,4,4-trichloro-3(S)-methyl-1-oxobutyl)amino]pentanoic acid

: 65647-65-6,67528-34-1,72258-37-8
dysidenin

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 - 25 ℃; for 12h; Inert atmosphere;
DOI:10.1002/asia.201100338

Reference yield:

: 1207363-08-3
(S)-4,4,4-trichloro-3-methylbutanenitrile

: 65647-65-6,67528-34-1,72258-37-8
dysidenin

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 25 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; sodium chlorite / 2-methyl-but-2-ene; water; tert-butyl alcohol / 3.33 h / 0 - 25 °C / Inert atmosphere

3.1: dicyclohexyl-carbodiimide / dichloromethane / 48.5 h / 0 - 25 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 14 h / 20 - 25 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 24 h / 0 - 25 °C / Inert atmosphere

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 12 h / 20 - 25 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 1-hydroxy-7-aza-benzotriazole; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; 2-methyl-but-2-ene; dichloromethane; water; mineral oil; tert-butyl alcohol;
DOI:10.1002/asia.201100338

Reference yield:

: 1207363-11-8
C₅H₇Cl₃O

: 65647-65-6,67528-34-1,72258-37-8
dysidenin

Guidance literature:: Multi-step reaction with 5 steps

1: sodium dihydrogenphosphate; sodium chlorite / 2-methyl-but-2-ene; water; tert-butyl alcohol / 3.33 h / 0 - 25 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide / dichloromethane / 48.5 h / 0 - 25 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrahydrofuran; water / 14 h / 20 - 25 °C / Inert atmosphere

4: sodium hydride / tetrahydrofuran; mineral oil / 24 h / 0 - 25 °C / Inert atmosphere

5: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 12 h / 20 - 25 °C / Inert atmosphere

With sodium chlorite; sodium dihydrogenphosphate; 1-hydroxy-7-aza-benzotriazole; sodium hydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; 2-methyl-but-2-ene; dichloromethane; water; mineral oil; tert-butyl alcohol;
DOI:10.1002/asia.201100338