1,3-dichloro-2-methyl-5-nitrobenzene

Base Information

• Chemical Name: 1,3-dichloro-2-methyl-5-nitrobenzene
• CAS No.: 7149-69-1
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• Hs Code.: 2904909090
• Mol file: 7149-69-1.mol

Synonyms:Toluene,2,6-dichloro-4-nitro- (8CI);1,3-Dichloro-2-methyl-5-nitrobenzene;2,6-Dichloro-4-nitrotoluene;NSC 72321;

Chemical Property of 1,3-dichloro-2-methyl-5-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.00674mmHg at 25°C
• Melting Point: 62-65ºC
• Refractive Index: 1.585
• Boiling Point: 279.6 °C at 760 mmHg
• Flash Point: 122.9 °C
• PSA: 45.82000
• Density: 1.456 g/cm³
• LogP: 3.73320
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1,3-Dichloro-2-methyl-5-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-dichloro-2-methyl-5-nitrobenzene

There total 12 articles about 1,3-dichloro-2-methyl-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-methyl-4-nitrobenzene (99-99-0) → 1,3-dichloro-2-methyl-5-nitrobenzene (7149-69-1)

Guidance literature:

1-methyl-4-nitrobenzene; With trichloroisocyanuric acid; sulfuric acid; at 60 ℃; for 20h;

With copper; In chlorobenzene; at 25 ℃; for 0.0833333h;

With acetic acid; In chlorobenzene; for 20h; Reflux;

DOI:10.1016/j.tet.2015.12.026

Reference yield:

2-(3,5-dichloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (942069-73-0) → 1,3-dichloro-2-methyl-5-nitrobenzene (7149-69-1)

Guidance literature:

With copper diacetate; triethylamine; sodium nitrite; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1002/chem.201901633

Reference yield:

1-methyl-4-nitrobenzene (99-99-0) → 2-chloro-4-nitrotoluene (121-86-8) + 1,3-dichloro-2-methyl-5-nitrobenzene (7149-69-1) + 2,3,6-trichloro-4-nitrotoluene (22548-85-2) + 2,3,5,6-tetrachloro-4-nitrotoluene (22490-21-7)

Guidance literature:

With iodine; chlorine; iron; In dichloromethane; at 25 ℃; Title compound not separated from byproducts;

DOI:10.1080/00397919308013809

upstream raw materials:

2-chloro-4-nitrotoluene

1-methyl-4-nitrobenzene

2,4-dichloro-3-methyl-6-nitro-aniline

chlorine

Downstream raw materials:

2,6-dichloro-3,4-dinitro-toluene

2-(bromomethyl)-1,3-dichloro-5-nitrobenzene

Refernces

• 1、 Li, Xuejing,Deng, Xingwang,Coyne, Anthony G.,Srinivasan, Rajavel. "meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation". supporting information. p. 8018 - 8023. Retrieved 2019/05/29.
• 2、 -. "A kind of the second aryl amine derivative and its preparation method, pharmaceutical composition and use thereof". Paragraph 0183; 0184; 0185. . Retrieved 2017/08/30.