Benzoic acid, 2-(acetylamino)-5-chloro-

Base Information

• Chemical Name: Benzoic acid, 2-(acetylamino)-5-chloro-
• CAS No.: 5202-87-9
• Molecular Formula: C9H8 Cl N O3
• Molecular Weight: 213.62
• Hs Code.: 2924299090
• Mol file: 5202-87-9.mol

Synonyms:Anthranilic acid, N-acetyl-5-chloro- (8CI);2-Acetamido-5-chlorobenzoic acid; 2-Acetylamino-5-chlorobenzoic acid;N-Acetyl-5-chloroanthranilic acid; NSC 404334

Chemical Property of Benzoic acid, 2-(acetylamino)-5-chloro-

Chemical Property:

• Vapor Pressure: 1.8E-08mmHg at 25°C
• Melting Point: 203-205℃
• Boiling Point: 438.7°Cat760mmHg
• Flash Point: 219.1°C
• PSA: 66.40000
• Density: 1.453g/cm³
• LogP: 2.06960

Purity/Quality:

99%min ^*data from raw suppliers

2-Acetamido-5-chlorobenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-(acetylamino)-5-chloro-

There total 8 articles about Benzoic acid, 2-(acetylamino)-5-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.36%

5-chloroanthranilic acid (635-21-2) + Cleland's reagent → N-(4-chloro-2-hydroxyphenyl)acetamide (16323-09-4) + 2-acetamido-5-chlorobenzoic acid (5202-87-9)

Guidance literature:

With oxygen; In aq. buffer; at 30 ℃; for 7h; pH=7; Microbiological reaction;

DOI:10.1021/acs.jafc.1c06910

Reference yield: 70.0%

N,N-dimethyloxamic acid (32833-96-8) + N-(4-chlorophenyl)acetamide (539-03-7) → 2-acetamido-5-chlorobenzoic acid (5202-87-9)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1039/c5cc07890c

Reference yield:

2-acetylamino-5-chloro-benzoic acid amide (7033-53-6) → 2-acetamido-5-chlorobenzoic acid (5202-87-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01187a033

upstream raw materials:

4-chloro-2-methylacetanilide

2-acetylamino-5-chloro-benzoic acid amide

acetic anhydride

5-chloroanthranilic acid

Downstream raw materials:

6-chloro-3-(2-methoxy-phenyl)-2-methyl-3H-quinazolin-4-one

6-chloro-2-methyl-3-phenylquinazolin-4(3H)-one

6-chloro-3-(4-ethoxy-phenyl)-2-methyl-3H-quinazolin-4-one

5-chloroanthranilic acid

Refernces

• 1、 Wu, Yinuo,Jiang, Cheng,Wu, Deyan,Gu, Qiong,Luo, Zhang-Yi,Luo, Hai-Bin. "Palladium-catalyzed C-H bond carboxylation of acetanilides: An efficient usage of N,N-dimethyloxamic acid as the carboxylate source". supporting information. p. 1286 - 1289. Retrieved 2016/01/15.
• 2、 Kim. "Rearrangement of 1,4 benzodiazepin 2,4 diones to 3,1 benzoxazin 4 ones by acetic anhydride". . p. 1165 - 1168. Retrieved 2007/10/05.