Tris(hydroxymethyl)phosphine

Base Information

• Chemical Name: Tris(hydroxymethyl)phosphine
• CAS No.: 2767-80-8
• Deprecated CAS: 15764-49-5,4568-60-9,4568-60-9
• Molecular Formula: C3H9O3P
• Molecular Weight: 124.076
• Hs Code.: 29310099
• European Community (EC) Number: 220-445-6
• UNII: Y6TG7WF7OQ
• DSSTox Substance ID: DTXSID0062634
• Nikkaji Number: J292.425K
• Wikipedia: Tris(hydroxymethyl)phosphine
• Wikidata: Q27294320
• ChEMBL ID: CHEMBL279546
• Mol file: 2767-80-8.mol

Synonyms:tris(hydroxymethyl)phosphine

Chemical Property of Tris(hydroxymethyl)phosphine

Chemical Property:

• Vapor Pressure: 4.9E-05mmHg at 25°C
• Melting Point: 48-56ºC(lit.)
• Boiling Point: 311.7°Cat760mmHg
• PKA: 13.19±0.10(Predicted)
• Flash Point: 142.3°C
• PSA: 74.28000
• Density: g/cm³
• LogP: -0.68230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: air sensitive
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 124.02893114
• Heavy Atom Count: 7
• Complexity: 31.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tris(hydroxymethyl)phosphine, min. 85% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): A poison by ingestion. A severe skin and eye irritant.
• Hazard Codes: T
• Statements: 25-41-37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(O)P(CO)CO

Technology Process of Tris(hydroxymethyl)phosphine

There total 11 articles about Tris(hydroxymethyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

tetrakis(hydroxymethyl)phosphonium chloride (124-64-1) → tris(hydroxymethyl)phosphine (2767-80-8)

Guidance literature:

tetrakis(hydroxymethyl)phosphonium chloride; With potassium hydroxide; In methanol; water; at 15 - 20 ℃; for 0.166667h;

With zinc(II) chloride; sodium sulfite; In methanol; water; at 25 ℃; Reagent/catalyst; Solvent;

Reference yield: 83.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) → tris(hydroxymethyl)phosphine (2767-80-8)

Guidance literature:

With phosphorus; tri-n-butyl-tin hydride; In ethanol; at 20 ℃; for 16h; Irradiation;

DOI:10.1038/s41557-021-00657-7

Reference yield: 60.0%

tetrakis(hydroxymethyl)phosphonium sulphate (55566-30-8) → tris-hydroxymethyl-phosphine oxide + tris(hydroxymethyl)phosphine (2767-80-8)

Guidance literature:

With sodium hydroxide; In water; for 0.0833333h;

upstream raw materials:

formaldehyd

tetrakis(hydroxymethyl)phosphonium chloride

chlorure de tetrakis(hydroxymethyl)phosphonium

tetrakis(hydroxymethyl)phosphonium sulphate

Downstream raw materials:

(1,3,5-triaza-7-phosphaadamantane)

Tris(o-carboxyphenylaminomethyl)phosphine

1,3,6-triaza-8-phospha-tricyclo[4.3.1.1^3,8]undecane

2,6,7-trioxa-1,4-diphospha-bicyclo[2.2.2]octane

Refernces

• 1、 Guerriero, Antonella,Oberhauser, Werner,Riedel, Tina,Peruzzini, Maurizio,Dyson, Paul J.,Gonsalvi, Luca. "New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent". . p. 5514 - 5518. Retrieved 2017.
• 2、 Goodwin, Nicholas J.,Henderson, William,Sarfo, J. Kwabena. "FcCH2P(CH2OH)2: A new, reactive yet air-stable ferrocene-derived phosphine [Fc = (η-C5H5)FeC5H4]". . p. 1551 - 1552. Retrieved 1996.
• 3、 -. "STABLE MODIFIED POLYMER POLYOL DISPERSIONS". Paragraph 0324-0325; 0344-0345; 0348-0349; 0356-0357. . Retrieved 2021/06/26.