Methyl 6-chloropicolinate

Base Information

• Chemical Name: Methyl 6-chloropicolinate
• CAS No.: 6636-55-1
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• European Community (EC) Number: 808-173-1
• NSC Number: 51592
• DSSTox Substance ID: DTXSID30287569
• Nikkaji Number: J124.915K
• Wikidata: Q72489426
• Mol file: 6636-55-1.mol

Synonyms:6636-55-1;Methyl 6-chloropicolinate;Methyl 6-chloro-2-pyridinecarboxylate;methyl 6-chloropyridine-2-carboxylate;2-Pyridinecarboxylic acid, 6-chloro-, methyl ester;6-Chloro-2-picolinic acid methyl ester;6-Chloropicolinic Acid Methyl Ester;MFCD00155391;Methyl 6-chloro-pyridine-2-carboxylate;METHYL 2-CHLOROPYRIDINE-6-CARBOXYLATE;6-chloro-pyridine-2-carboxylic acid methyl ester;Enamine_000452;SCHEMBL400889;DTXSID30287569;HMS1395E12;BCP21041;NSC51592;BBL028292;CL0084;NSC-51592;STK858461;AKOS000269663;ISOBUTYLHYDROGENMETHYLPHOSPHONATE;6-Chloro-2-Picolinic Acid Methylester;AC-3382;CS-W002452;MB00777;MS-3561;6-Chloro-2-picolinic acid, methyl ester;SY007550;A8954;FT-0659118;M2640;EN300-124201;6-chloro-2-pyridinecarboxylic acid, methyl ester;6-chloro-2-picolinic acid methyl ester, AldrichCPR;J-522550;Z56771184;6-CHLORO-2-PYRIDINECARBOXYLIC ACID METHYL ESTER

Chemical Property of Methyl 6-chloropicolinate

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 93-94oC
• Refractive Index: 1.531
• Boiling Point: 275.832oC at 760 mmHg
• PKA: -1.03±0.10(Predicted)
• Flash Point: 120.619oC
• PSA: 39.19000
• Density: 1.295g/cm3
• LogP: 1.52160
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 171.0087061
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-2-picolinicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=NC(=CC=C1)Cl
• Uses: Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.

Technology Process of Methyl 6-chloropicolinate

There total 12 articles about Methyl 6-chloropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 6-chloropicolinic acid (4684-94-0) → methyl 6-chloropicolinate (6636-55-1)

Guidance literature:

With thionyl chloride; at 0 - 50 ℃; for 6.75h;

Reference yield: 83.0%

6-chloropicolinic acid (4684-94-0) + Methyl trichloroacetate (598-99-2) → methyl 6-chloropicolinate (6636-55-1)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; at 90 - 150 ℃; for 2h;

Reference yield: 81.0%

2,6-dichloropyridine (2402-78-0) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 2,6-bis(methoxycarbonyl)pyridine (5453-67-8) + methyl 6-chloropicolinate (6636-55-1)

Guidance literature:

With triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; at 140 ℃; for 6h; under 37503 Torr;

DOI:10.1016/S0040-4039(99)00597-3

upstream raw materials:

6-chloropicolinic acid

2,6-Dibromopyridine

methanol

carbon dioxide

Downstream raw materials:

methyl-6-(3-α,α,α-trifluoromethylphenoxy)-picolinate

2-chloro-6-(bromomethyl)pyridine

Refernces

• 1、 -. "N,6-BIS(ARYL OR HETEROARYL)-1,3,5-TRIAZINE-2,4-DIAMINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER". Page/Page column 52; 53. . Retrieved 2015/02/02.
• 2、 -. "THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE". Page/Page column 117. . Retrieved 2013/07/19.