(4-Methoxyphenyl)(naphthalen-2-yl)methanone

Base Information

• Chemical Name: (4-Methoxyphenyl)(naphthalen-2-yl)methanone
• CAS No.: 39070-97-8
• Molecular Formula: C18H14O2
• Molecular Weight: 262.308
• NSC Number: 107525
• DSSTox Substance ID: DTXSID40296081
• Nikkaji Number: J1.836.269D
• Wikidata: Q82036421
• Mol file: 39070-97-8.mol

Synonyms:(4-methoxyphenyl)(naphthalen-2-yl)methanone;39070-97-8;NSC107525;SCHEMBL6557518;DTXSID40296081;NNXQMTKVUIFOIV-UHFFFAOYSA-N;4-Methoxyphenyl 2-naphthyl ketone;2-naphthyl 4-meth-oxyphenyl ketone;NSC-107525;P-METHOXYPHENYL-2-NAPHTHYLKETONE

Chemical Property of (4-Methoxyphenyl)(naphthalen-2-yl)methanone

Chemical Property:

• Vapor Pressure: 6.3E-08mmHg at 25°C
• Refractive Index: 1.632
• Boiling Point: 439.6 °C at 760 mmHg
• Flash Point: 202 °C
• Density: 1.162 g/cm³
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 262.099379685
• Heavy Atom Count: 20
• Complexity: 330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC3=CC=CC=C3C=C2

Technology Process of (4-Methoxyphenyl)(naphthalen-2-yl)methanone

There total 34 articles about (4-Methoxyphenyl)(naphthalen-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-methoxyphenyl1-naphthylmethanol acetate → (4-methoxyphenyl)(2-naphthyl)methanone (39070-97-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; chlorobenzene; at 130 ℃; for 1.5h;

Reference yield: 98.0%

naphthalene-2-boronic acid (32316-92-0) + 4-methoxybenzonitrile (874-90-8) → (4-methoxyphenyl)(2-naphthyl)methanone (39070-97-8)

Guidance literature:

With trifluorormethanesulfonic acid; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine; In water; at 90 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2014.11.009

Reference yield: 94.0%

4-methoxyphenylboronic acid (5720-07-0) + 1-(2-naphthoyl)pyrrolidine-2,5-dione → (4-methoxyphenyl)(2-naphthyl)methanone (39070-97-8)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In toluene; at 110 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2017.08.044

upstream raw materials:

2-naphthalenecarbonitrile

4-methoxyphenyl magnesium bromide

methoxybenzene

2-naphthaloyl chloride

Downstream raw materials:

(4-Hydroxy-3,5-diiodo-phenyl)-naphthalen-2-yl-methanone

(3,5-Dibromo-4-hydroxy-phenyl)-naphthalen-2-yl-methanone

Refernces

• 1、 Li, Guangchen,Szostak, Michal. "Synthesis of biaryl ketones by arylation of Weinreb amides with functionalized Grignard reagents under thermodynamic controlvs.kinetic control ofN,N-Boc2-amides". supporting information. p. 3827 - 3831. Retrieved 2020/06/03.
• 2、 Dardir, Amira H.,Melvin, Patrick R.,Davis, Ryan. M.,Hazari, Nilay,Mohadjer Beromi, Megan. "Rapidly Activating Pd-Precatalyst for Suzuki-Miyaura and Buchwald-Hartwig Couplings of Aryl Esters". supporting information. p. 469 - 477. Retrieved 2018/02/19.