3,4,5,6-TETRACHLOROPYRIDAZINE

Base Information

• Chemical Name: 3,4,5,6-TETRACHLOROPYRIDAZINE
• CAS No.: 20074-67-3
• Molecular Formula: C4Cl4N2
• Molecular Weight: 217.869
• Hs Code.: 2933990090
• Mol file: 20074-67-3.mol

Synonyms:Pyridazine,tetrachloro- (6CI,7CI,8CI,9CI);NSC 71101;Tetrachloropyridazine;

Chemical Property of 3,4,5,6-TETRACHLOROPYRIDAZINE

Chemical Property:

• Vapor Pressure: 7.35E-05mmHg at 25°C
• Melting Point: 87-89 °C
• Refractive Index: 1.594
• Boiling Point: 353.3 °C at 760 mmHg
• PKA: -4.31±0.10(Predicted)
• Flash Point: 198.6 °C
• PSA: 25.78000
• Density: 1.761g/cm³
• LogP: 3.09020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3,4,5,6-tetrachloropyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4,5,6-TETRACHLOROPYRIDAZINE

There total 5 articles about 3,4,5,6-TETRACHLOROPYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4,5,6-trichloro-2H-pyridazin-3-one (17285-31-3) → tetrachloropyridazine (20074-67-3)

Guidance literature:

With Vilsmeier reagent; In toluene; for 4h; Heating;

DOI:10.1002/jhet.5570330659

Reference yield: 96.0%

4,5-dichloro-6-nitropyridazin-3(2H)-one (13645-43-7) → tetrachloropyridazine (20074-67-3)

Guidance literature:

With Vilsmeier reagent; In toluene; for 1h; Heating;

DOI:10.1002/jhet.5570330659

Reference yield: 40.0%

4,5-dichloro-6-hydroxypyridazin-3(2H)-one (6641-32-3) → tetrachloropyridazine (20074-67-3)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1021/acs.joc.6b00630

upstream raw materials:

4,5-dichloromaleic hydrazide

4,5,6-trichloro-2H-pyridazin-3-one

4,5-dichloro-6-nitropyridazin-3(2H)-one

4,5-dichloro-6-hydroxypyridazin-3(2H)-one

Downstream raw materials:

tetrachloropyrazine

N-benzyl-3,5,6-trichloropyridazin-4-amine

Refernces

• 1、 Kang,Woo Song Lee,Kim,Yoon,Shiro. "Chlorination of 3,4,5-trichloropyridazin-6-one and synthesis of 3,4,5-trichloro-1-(4,5,6-trichloropyridazin-3-yl)pyridazin-6-one". . p. 1049 - 1053. Retrieved 2000.
• 2、 -. "TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS". Page/Page column 71. . Retrieved 2013/03/26.