Cyclohexanepropanoic acid,â-hydroxy-

Base Information

• Chemical Name: Cyclohexanepropanoic acid,â-hydroxy-
• CAS No.: 4354-62-5
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.224
• Mol file: 4354-62-5.mol

Synonyms:

Chemical Property of Cyclohexanepropanoic acid,â-hydroxy-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanepropanoic acid,â-hydroxy-

There total 9 articles about Cyclohexanepropanoic acid,â-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Iodoacetic acid (64-69-7) + cyclohexanecarbaldehyde (2043-61-0) → 3-cyclohexyl-3-hydroxypropanoic acid (4354-62-5)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 25 ℃; for 3.5h;

DOI:10.1021/jo060118j

Reference yield: 83.0%

rac-3-cyclohexyl-3-hydroxypropionitrile (126678-67-9) → 3-cyclohexyl-3-hydroxypropanoic acid (4354-62-5)

Guidance literature:

With phosphate buffer; for 24h; immobilized nitrilase from Rhodococcus sp.;

DOI:10.1016/S0040-4039(00)92623-6

Reference yield: 39.0%

rac-3-cyclohexyl-3-hydroxypropionitrile (126678-67-9) → 3-cyclohexyl-3-hydroxypropanoic acid (4354-62-5) + 3-cyclohexyl-3-hydroxypropanamide (4354-61-4)

Guidance literature:

With phosphate buffer; for 1h; immobilized nitrilase from Rhodococcus sp.;

DOI:10.1016/S0040-4039(00)92623-6

upstream raw materials:

propynoic acid ethyl ester

cyclohexene

rac-3-cyclohexyl-3-hydroxypropionitrile

carbon dioxide

Downstream raw materials:

C₁₅H₃₂O₃Si₂

(R)-3-Cyclohexyl-3-hydroxy-propionic acid

Refernces

• 1、 Bonnett, Shilah A.,Whicher, Jonathan R.,Papireddy, Kancharla,Florova, Galina,Smith, Janet L.,Reynolds, Kevin A.. "Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene". . p. 772 - 783. Retrieved 2013/07/26.
• 2、 Klempier,De Raadt,Faber,Grieng. "Selective transformation of nitriles into amides and carboxylic acids by an immobilized nitrilase". . p. 341 - 344. Retrieved 2007/10/02.