3-Hydroxy-4-aminobiphenyl

Base Information

• Chemical Name: 3-Hydroxy-4-aminobiphenyl
• CAS No.: 4363-03-5
• Deprecated CAS: 88847-42-1
• Molecular Formula: C12H11 N O
• Molecular Weight: 185.225
• Hs Code.: 2922199090
• UNII: 4VL6M84QS6
• DSSTox Substance ID: DTXSID1020720
• Nikkaji Number: J41.828E
• Wikidata: Q63088224
• Mol file: 4363-03-5.mol

Synonyms:3-hydroxy-4-aminobiphenyl;3-hydroxy-4-aminobiphenyl sulfate (1:1)

Chemical Property of 3-Hydroxy-4-aminobiphenyl

Chemical Property:

• Vapor Pressure: 2.2E-05mmHg at 25°C
• Melting Point: 183°C
• Refractive Index: 1.5300 (estimate)
• Boiling Point: 350.3°Cat760mmHg
• PKA: 9.53±0.10(Predicted)
• Flash Point: 165.6°C
• PSA: 46.25000
• Density: 1.191g/cm³
• LogP: 3.22260
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 185.084063974
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

3-HYDROXY-4-AMINOBIPHENYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=C(C=C2)N)O

Technology Process of 3-Hydroxy-4-aminobiphenyl

There total 4 articles about 3-Hydroxy-4-aminobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-nitro 5-phenyl phenol (18062-89-0) → 2-amino 5-phenyl phenol (4363-03-5,88847-42-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2012.07.023

Reference yield:

[1,1'-biphenyl]-3-ol (580-51-8) → 2-amino 5-phenyl phenol (4363-03-5,88847-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / acetic acid / 0.5 h / 20 °C / Cooling with ice

2: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C

With palladium 10% on activated carbon; hydrogen; nitric acid; In methanol; acetic acid;

DOI:10.1016/j.bmc.2012.07.023

Reference yield:

sulfuric acid mono-(4-amino-biphenyl-3-yl ester) (3365-93-3) → 2-amino 5-phenyl phenol (4363-03-5,88847-42-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1039/jr9540000980

upstream raw materials:

2-nitro 5-phenyl phenol

sulfuric acid mono-(4-amino-biphenyl-3-yl ester)

4-phenylalanine

[1,1'-biphenyl]-3-ol

Downstream raw materials:

tert-butyl (2-oxo-6-phenyl-1,3-benzoxazol-3(2H)-yl)acetate

(2-oxo-6-phenyl-1,3-benzoxazol-3(2H)-yl)acetic acid

C₂₂H₁₈N₂O₃

6-phenyl-1,3-benzoxazol-2(3H)-one

Refernces

• 1、 -. "IL-8 RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.
• 2、 -. "IL-8 RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.