2-(Difluoromethoxy)-1,1,1-trifluoroethane

Base Information

• Chemical Name: 2-(Difluoromethoxy)-1,1,1-trifluoroethane
• CAS No.: 1885-48-9
• Molecular Formula: C3H3F5O
• Molecular Weight: 150.048
• Hs Code.: 2909191800
• European Community (EC) Number: 413-830-7,642-359-1
• UNII: 986WJ01025
• DSSTox Substance ID: DTXSID5073951
• Nikkaji Number: J668.547A
• Wikidata: Q27272092
• Mol file: 1885-48-9.mol

Synonyms:DFM-TFE;difluoromethyl 2,2,2-trifluoroethyl ether

Chemical Property of 2-(Difluoromethoxy)-1,1,1-trifluoroethane

Chemical Property:

• Vapor Pressure: 0.0055mmHg at 25°C
• Melting Point: -23.15°C
• Refractive Index: 1.566
• Boiling Point: 13.3 °C at 760 mmHg
• Flash Point: 112.5°C
• PSA: 9.23000
• Density: 1.338 g/cm³
• LogP: 1.78790
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 150.01040553
• Heavy Atom Count: 9
• Complexity: 76.8

Purity/Quality:

99%, ^*data from raw suppliers

DIFLUOROMETHYL 2,2,2-TRIFLUOROETHYL ETHER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(F)(F)F)OC(F)F
• Uses: Difluoromethyl 2,2,2-Trifluoroethyl Ether can be used as a secondary battery separator layer, electrode structure, and secondary battery.

Technology Process of 2-(Difluoromethoxy)-1,1,1-trifluoroethane

There total 8 articles about 2-(Difluoromethoxy)-1,1,1-trifluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,2,2-trifluoroethanol (75-89-8) + 2,2-difluoro-2-(fluorosulfonyl)acetic acid (1717-59-5) → trifluoromethan (75-46-7) + 1,1,1-trifluoro-2-difluoromethoxypropane (1885-48-9)

Guidance literature:

sodium sulfate; In acetonitrile; at 45 ℃; for 2h;

DOI:10.1016/S0022-1139(00)82808-0

Reference yield: 43.0%

Chlorodifluoromethane (75-45-6) + 2,2,2-trifluoroethanol (75-89-8) → 1,1,1-trifluoro-2-difluoromethoxypropane (1885-48-9)

Guidance literature:

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 30 ℃; for 3h; Autoclave; Cooling with ice;

Reference yield:

Hexafluoropropene oxide (428-59-1,25038-02-2) + 2,2,2-trifluoroethanol (75-89-8) → perfluoropropylene (116-15-4,13429-24-8,25120-07-4,6792-31-0) + trifluoromethan (75-46-7) + 1,1,1-trifluoro-2-difluoromethoxypropane (1885-48-9) + 1,1,2,2,3,3-Hexafluoro-cyclopropane (931-91-9)

Guidance literature:

at 160 ℃; for 48h;

DOI:10.1016/j.jfluchem.2005.01.012

upstream raw materials:

Chlorodifluoromethane

2,2,2-trifluoroethanol

2,2,2-Trifluorethyl-dichlormethylether

3,3-difluoro-3H-diazirine

Downstream raw materials:

1-Brom-2,2,2-trifluorethyl-difluormethyl-ether

(Chlor-difluormethyl)-(2,2,2-trifluor-ethyl)-ether

(Chlor-difluor-methyl)-(1,1-dichlor-2,2,2-trifluor-ethyl)-ether

1,1-Dichloro-2,2,2-trifluoroethyl difluoromethyl ether

Refernces

• 1、 Flynn, Richard M.,Burton, Donald J.. "Synthetic and mechanistic aspects of halo-F-methylphosphonates". experimental part. p. 815 - 828. Retrieved 2011/10/08.
• 2、 Mizukado, Junji,Matsukawa, Yasuhisa,Quan, Heng-Dao,Tamura, Masanori,Sekiya, Akira. "Insertion reactions of difluorocarbene generated by pyrolysis of hexafluoropropene oxide to O-H bond". . p. 373 - 377. Retrieved 2007/10/03.