2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE

Base Information

• Chemical Name: 2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE
• CAS No.: 6280-52-0
• Molecular Formula: C14H11 Cl O2
• Molecular Weight: 246.693
• Hs Code.: 2914700090
• Mol file: 6280-52-0.mol

Synonyms:Benzophenone,2'-chloro-2-hydroxy-5-methyl- (6CI,8CI);2'-Chloro-2-hydroxy-5-methylbenzophenone; NSC 11161

Chemical Property of 2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE

Chemical Property:

• Vapor Pressure: 4.13E-06mmHg at 25°C
• Melting Point: 75-78 °C(lit.)
• Boiling Point: 373.6°C at 760 mmHg
• Flash Point: 179.7°C
• PSA: 37.30000
• Density: 1.27g/cm³
• LogP: 3.58500

Purity/Quality:

98%min ^*data from raw suppliers

2′-Chloro-2-hydroxy-5-methylbenzophenone 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE

There total 9 articles about 2'-CHLORO-2-HYDROXY-5-METHYLBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(2-chlorophenyl)-5-methylbenzofuran-2(3H)-one → (2-chlorophenyl)(2-hydroxy-5-methylphenyl)methanone (6280-52-0)

Guidance literature:

With tert.-butylhydroperoxide; sodium carbonate; nickel dichloride; In toluene; at 80 ℃; for 12h; Schlenk technique;

DOI:10.1021/acs.joc.0c00858

Reference yield: 31.0%

p-cresol (106-44-5) + ortho-chlorobenzoic acid (118-91-2) → (2-chlorophenyl)(2-hydroxy-5-methylphenyl)methanone (6280-52-0)

Guidance literature:

With methanesulfonic acid; pyrographite; at 120 ℃;

DOI:10.1016/j.tet.2009.05.021

Reference yield:

2-chloro-benzoic acid p-tolyl ester (6280-48-4) → (2-chlorophenyl)(2-hydroxy-5-methylphenyl)methanone (6280-52-0)

Guidance literature:

With aluminium trichloride; at 140 ℃;

upstream raw materials:

p-cresol

2-chlorobenzotrichloride

2-chloro-benzoic acid p-tolyl ester

o-chlorobenzoyl chloride

Downstream raw materials:

ethyl (N'-{2-[2-(2-chlorobenzoyl)-4-methylphenoxy]acetyl}hydrazinocarbonyl)acetate

2-[2-(2-chlorobenzoyl)-4-methylphenoxy]acetohydrazide

2-(2-chloro-benzyl)-1-(3,5-dinitro-benzoyloxy)-4-methyl-benzene

ethyl [2-(2-chlorobenzoyl)-4-methylphenoxy]acetate

Refernces

• 1、 Barbero, Nekane,SanMartin, Raul,Domínguez, Esther. "A convenient approach to the xanthone scaffold by an aqueous aromatic substitution of bromo- and iodoarenes". supporting information; experimental part. p. 5729 - 5732. Retrieved 2009/11/30.