N-TERT-BUTYLACETAMIDE

Base Information

• Chemical Name: N-TERT-BUTYLACETAMIDE
• CAS No.: 762-84-5
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2924199090
• Mol file: 762-84-5.mol

Synonyms:Acetamide,N-tert-butyl- (6CI,7CI,8CI);2-Acetamido-2-methylpropane;N-(1,1-Dimethylethyl)acetamide;N-tert-Butylacetamide;NSC 131312;

Chemical Property of N-TERT-BUTYLACETAMIDE

Chemical Property:

• Vapor Pressure: 0.345mmHg at 25°C
• Melting Point: 96-98 °C
• Refractive Index: 1.414
• Boiling Point: 199.2 °C at 760 mmHg
• PKA: 16.60±0.46(Predicted)
• Flash Point: 102 °C
• PSA: 29.10000
• Density: 0.862 g/cm³
• LogP: 1.31190
• Water Solubility.: Soluble in water.

Purity/Quality:

99%, ^*data from raw suppliers

N-tert-Butylacetamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It finds its application in the synthesis of amides using the Ritter reaction with bismuth triflate catalysis.

Technology Process of N-TERT-BUTYLACETAMIDE

There total 118 articles about N-TERT-BUTYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetonitrile (75-05-8,26809-02-9) + tert-butyl alcohol (75-65-0) → N-tert-butylacetamide (762-84-5)

Guidance literature:

With Selectfluor; Diphenylphosphine oxide; at 60 ℃; for 24h;

DOI:10.1021/acs.joc.6b01932

Reference yield: 100.0%

C25H26F3N5O3 + acetonitrile (75-05-8,26809-02-9) → N-tert-butylacetamide (762-84-5) + C20H18F3N5O (1245013-80-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1016/j.bmcl.2010.06.072

Reference yield: 99.0%

acetic anhydride (108-24-7) + tert-butylamine (75-64-9) → N-tert-butylacetamide (762-84-5)

Guidance literature:

acetic anhydride; With molybdenium(VI) dioxodichloride; In dichloromethane; at 20 ℃; for 0.5h;

tert-butylamine; In dichloromethane; at 20 ℃; for 0.1h;

DOI:10.1021/jo048363v

upstream raw materials:

pinacolone oxime

acetic anhydride

tert-butylamine

acetic acid

Downstream raw materials:

N-t-butylethylamine

trans-1,2-dibromocyclohexane

N-tert-Butyl-(trimethylsilyl)-acetamid

(S)-benzyl (1-(tert-butylamino)-1-oxo-3-phenylpropan-2-yl)carbamate

Refernces

• 1、 Jovi?, Branislav,Nikoli?, Aleksandar,Petrovi?. "FTIR spectroscopic study of hydrogen bonding and solvent induced frequency shifts of N-tert-butylacetamide". . p. 140 - 143. Retrieved 2013.
• 2、 -. "Preparation method of acetamide compound". Paragraph 0035-0047. . Retrieved 2021/05/19.
• 3、 Nandy, Sneha,Das, Asit Kumar,Bhar, Sanjay. "Chemoselective formation of C–N bond in wet acetonitrile using amberlyst-15(H) as a recyclable catalyst". supporting information. p. 3326 - 3336. Retrieved 2020/08/13.