3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid

Base Information

• Chemical Name: 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid
• CAS No.: 14939-91-4
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Hs Code.: 2932999099
• Mol file: 14939-91-4.mol

Synonyms:1,4-Benzodioxan-6-acrylicacid (8CI);1,4-Benzodioxin, 2-propenoic acid deriv.;3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid;(2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)prop-2-enoate;

Chemical Property of 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid

Chemical Property:

• Vapor Pressure: 2.36E-06mmHg at 25°C
• Melting Point: 196-198 °C
• Boiling Point: 377 °C at 760 mmHg
• Flash Point: 151.6 °C
• PSA: 55.76000
• Density: 1.339
• LogP: 1.55560
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2E)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid

There total 5 articles about 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde (29668-44-8) → (E)-3,4-ethylenedioxycinnamic acid (14939-91-4)

Guidance literature:

With piperidine; pyridine;

Reference yield:

methyl (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylate → (E)-3,4-ethylenedioxycinnamic acid (14939-91-4)

Guidance literature:

With water; sodium hydroxide; at 80 ℃;

DOI:10.1134/S0022476617040229

Reference yield:

piperidine (110-89-4) + 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde (29668-44-8) → (E)-3,4-ethylenedioxycinnamic acid (14939-91-4)

Guidance literature:

With malonic acid; In pyridine; sodium hydroxide;

upstream raw materials:

malonic acid

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

piperidine

caffeic acid

Downstream raw materials:

(1R,2R)-octanoic acid [2-(2',3'-dihydro-benzo[1,4]dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide

(1R,2R)-2-amino-1-(2,3-dihydrobenzo[β][1,4]dioxin-6-yl)-3-pyrrolidin-1-yl-propan-1-ol

Refernces

• 1、 Chen,Wang,Kong,Li,Zhou,Zhang,Sheng,Zhu. "Structure and urease inhibitory activity of copper(II) complex with (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid". . p. 797 - 803. Retrieved 2017.
• 2、 -. "STABLE N-((1R,2R)-1-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-6-YL)-1-HYDROXY-3-(PYRROLIDIN-1-YL)PROPAN-2-YL) OCTANAMIDE (2R,3R)-2,3-DIHYDROXYSUCCINATE PREMIX AND PROCESS FOR PREPARATION THEREOF". Page/Page column 23. . Retrieved 2019/05/15.
• 3、 Yu, Pan,Xia, Chao-Jie,Li, Dong-Dong,Ni, Jun-Jun,Zhao, Lin-Guo,Ding, Gang,Wang, Zhen-Zhong,Xiao, Wei. "Design, synthesis, and anti-inflammatory activity of caffeoyl salicylate analogs as NO production inhibitors". . p. 25 - 33. Retrieved 2018/06/26.