2-(biphenyl-4-yl)-2-oxoethyl acetate

Base Information

• Chemical Name: 2-(biphenyl-4-yl)-2-oxoethyl acetate
• CAS No.: 4376-27-6
• Molecular Formula: C16H14O3
• Molecular Weight: 254.2806
• Mol file: 4376-27-6.mol

Synonyms:

Chemical Property of 2-(biphenyl-4-yl)-2-oxoethyl acetate

Chemical Property:

• Vapor Pressure: 1.77E-06mmHg at 25°C
• Boiling Point: 395.9°Cat760mmHg
• Flash Point: 175.5°C
• Density: 1.141g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(biphenyl-4-yl)-2-oxoethyl acetate

There total 16 articles about 2-(biphenyl-4-yl)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Bromo-4'-phenylacetophenone (135-73-9) → 2-acetoxy-4'-phenylacetophenone (4376-27-6)

Guidance literature:

With silver(I) acetate; In acetonitrile; at 50 ℃; for 1.5h; Inert atmosphere; Darkness;

DOI:10.1055/s-0033-1338551

Reference yield: 98.0%

acetic acid (64-19-7,77671-22-8) + 2-Bromo-4'-phenylacetophenone (135-73-9) → 2-acetoxy-4'-phenylacetophenone (4376-27-6)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1021/ac50064a047

Reference yield: 88.3%

sodium acetate (127-09-3) + 2-Bromo-4'-phenylacetophenone (135-73-9) → 2-acetoxy-4'-phenylacetophenone (4376-27-6)

Guidance literature:

With acetic acid; In ethanol; water; for 2.5h; Heating;

DOI:10.1021/jm0602256

upstream raw materials:

2-diazo-1-biphenyl-4-yl-ethanone

acetic acid

2-Bromo-4'-phenylacetophenone

potassium acetate

Downstream raw materials:

[1,1'-biphenyl]-4-yl(4-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)methanone

Refernces

• 1、 Liberatore, Anne-Marie,Schulz, Jocelyne,Pommier, Jacques,Barthelemy, Marie-Anne,Huchet, Marion,Chabrier, Pierre-Etienne,Bigg, Dennis. "2-Alkyl-4-arylimidazoles: Structurally novel sodium channel modulators". . p. 3521 - 3523. Retrieved 2004.
• 2、 Zhou, Xiaoqiang,Ma, Haojie,Cao, Jinhui,Liu, Xingxing,Huang, Guosheng. "Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process". supporting information. p. 10070 - 10073. Retrieved 2016/11/06.
• 3、 Kaila, Neelu,Janz, Kristin,DeBernardo, Silvano,Bedard, Patricia W.,Camphausen, Raymond T.,Tam, Steve,Tsao, Desirée H.H.,Keith Jr., James C.,Nickerson-Nutter, Cheryl,Shilling, Adam,Young-Sciame, Ruth,Wang, Qin. "Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists". . p. 21 - 39. Retrieved 2008/02/02.