Ractopamine hydrochloride

Base Information

• Chemical Name: Ractopamine hydrochloride
• CAS No.: 90274-24-1
• Molecular Formula: C18H24ClNO3
• Molecular Weight: 337.846
• Hs Code.: 2922504500
• Mol file: 90274-24-1.mol

Synonyms:Benzenemethanol, 4-hydroxy-α-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]-, hydrochloride (9CI);EL 737;LY 031537;Optaflexx;Paylean;Ractopamine hydrochloride;Topmax 9;

Chemical Property of Ractopamine hydrochloride

Chemical Property:

• Appearance/Colour: White to almost white Crystalline powder
• Vapor Pressure: 1.36E-12mmHg at 25°C
• Melting Point: 165-167 °C
• Boiling Point: 542.3 °C at 760 mmHg
• Flash Point: 281.8 °C
• PSA: 72.72000
• LogP: 3.93500
• Storage Temp.: 0-6°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

rac Ractopamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/22:; R43:
• Hazard Codes: Xn,T,F
• Statements: 20/22-43-39/23/24/25-23/24/25-11
• Safety Statements: 24-26-37-45-36/37-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Ractopamine hydrochloride is a phenethanolamine β-adrenergic agonist that redirects nutrients away from fat deposition and towards lean deposition. The mode of action of ractopamine primarily involves the modulation of metabolic pathways and signals in muscle and lipid cells to enhance protein accretion. Other mechanisms also include regulation of hormone release and modification of blood flow (Mersmann, 1998). It has the effects of increasing muscle mass and decreasing body fat in rodents and lifestock.
• Uses: Ractopamine hydrochloride (RAC) is a adrenergic β-agonist approved by the U.S. Food and Drug Administration (FDA) as a medicated feed ingredient for cattle during the final days of finishing to improve feed efficiency and growth.
• Biological Functions: Ractopamine is a feed additive marketed by Elanco Animal Health in the US for swine (Paylean?), cattle (Optaflexx?), and turkeys (Topmax?). Zoetis also markets generic versions for swine (Engain?) and cattle (Actogain?). Ractopamine is intended to provide economic benefits by increasing rate of gain, improving feed efficiency, and increasing carcass leanness. The active ingredient is ractopamine hydrochloride, a synthetic, racemic biogenic amine, and a Beta-adrenoceptor agonists (β-agonists or beta-agonists). β-agonists are anabolic compounds that promote fat loss and muscle gain. It is not an antibiotic, hormone, or steroid.

Technology Process of Ractopamine hydrochloride

There total 2 articles about Ractopamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4'-hydroxyphenyl)but-3-en-2-one (22214-30-8,59417-71-9,3160-35-8) + octopamine hydrochloride (770-05-8) → 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino]ethanol hydrochloride (90274-24-1,99095-19-9)

Guidance literature:

octopamine hydrochloride; With sodium hydrogencarbonate; In methanol; at 20 ℃;

4-(4'-hydroxyphenyl)but-3-en-2-one; With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

With hydrogenchloride; In water; pH=3 - 4; Reagent/catalyst;

Reference yield:

1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol (97825-25-7,66734-12-1) → 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino]ethanol hydrochloride (90274-24-1,99095-19-9)

Guidance literature:

With hydrogenchloride; In water;

Reference yield:

1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino]ethanol hydrochloride (90274-24-1,99095-19-9) → 1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol (97825-25-7,66734-12-1)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

upstream raw materials:

1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol

4-(4'-hydroxyphenyl)but-3-en-2-one

octopamine hydrochloride

Downstream raw materials:

1-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)-1-methylpropylamino]ethanol

Refernces

• 1、 -. "Methods of Accelerating Muscle Growth, Decreasing Fat Deposits and Improving Feed Efficiency in Livestock Animals". Page/Page column 13. . Retrieved 2008/06/13.