Ethyl O-Mesitylsulfonylacetohydroxamate

Base Information

• Chemical Name: Ethyl O-Mesitylsulfonylacetohydroxamate
• CAS No.: 38202-27-6
• Molecular Formula: C13H19NO4S
• Molecular Weight: 285.364
• Hs Code.: 29252900
• European Community (EC) Number: 253-825-5
• Mol file: 38202-27-6.mol

Synonyms:Ethyl O-Mesitylsulfonylacetohydroxamate;38202-27-6;Ethyl N-(mesitylsulfonyl)oxyacetimidate;Ethyl O-methylsulphonylacetohydroxamate;Ethyl O-(2-mesitylenesulfonyl)acethydroxamate;EINECS 253-825-5;ethyl (1E)-N-(2,4,6-trimethylphenyl)sulfonyloxyethanimidate;MFCD00009244;ethyl (1Z)-N-[(mesitylsulfonyl)oxy]ethanimidoate;O-Mesitylsulfonylacetohydroxamic Acid Ethyl Ester;SCHEMBL957952;KQCBSWBQAXTILK-OWBHPGMISA-N;AKOS015843284;CS-W008041;(Z)-ethyl N-mesitylsulfonyloxyacetimidate;DS-13518;(Z)-ethyl N-(mesitylsulfonyl)oxyacetimidate;M1182;4-(MORPHOLINE-4-SULFONYL)-BENZOICACID;Ethyl O-(2-mesitylenesulfonyl)acetohydroxamate;Ethyl O-(2-mesitylenesulfonyl)acethydroxamate, 98%;J-521272;Ethyl O-(2-mesitylenesulfonyl)acethydroxamate, purum, >=97.0% (HPLC)

Chemical Property of Ethyl O-Mesitylsulfonylacetohydroxamate

Chemical Property:

• Appearance/Colour: white to light yellow crystalline powder
• Vapor Pressure: 1.09E-05mmHg at 25°C
• Melting Point: 54-56 °C(lit.)
• Refractive Index: 1.515
• Boiling Point: 381.7 °C at 760 mmHg
• Flash Point: 184.7 °C
• PSA: 73.34000
• Density: 1.155 g/cm³
• LogP: 3.76780
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 285.10347926
• Heavy Atom Count: 19
• Complexity: 401

Purity/Quality:

99% ^*data from raw suppliers

EthylN-(Mesitylsulfonyl)oxyacetimidate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=NOS(=O)(=O)C1=C(C=C(C=C1C)C)C)C
• Isomeric SMILES: CCO/C(=N/OS(=O)(=O)C1=C(C=C(C=C1C)C)C)/C

Technology Process of Ethyl O-Mesitylsulfonylacetohydroxamate

There total 4 articles about Ethyl O-Mesitylsulfonylacetohydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

2-mesitylenesulphonyl chloride (773-64-8) + ethyl acetohydroximate (10576-12-2) → ethyl O-(2-mesitylenesulfonyl)acetohydroxamate (38202-27-6)

Guidance literature:

ethyl acetohydroximate; With triethylamine; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 0.166667h;

2-mesitylenesulphonyl chloride; In N,N-dimethyl-formamide; at 0 - 10 ℃; for 1h;

DOI:10.1039/c8ra02491j

Reference yield: 92.0%

ethyl acetohydroximate (10576-12-2) + 2-bromomesitylene (1667-04-5) → ethyl O-(2-mesitylenesulfonyl)acetohydroxamate (38202-27-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

ethyl acetohydroximate (10576-12-2) + 2-Mesitylenesulfonyl chloride → ethyl O-(2-mesitylenesulfonyl)acetohydroxamate (38202-27-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.75h;

DOI:10.1002/ardp.201300379

upstream raw materials:

2-mesitylenesulphonyl chloride

ethyl acetohydroximate

2-bromomesitylene

Downstream raw materials:

2-aminopyrazolo[1,5-a]pyridine

C₇H₁₁N₂O⁽¹⁺⁾*C₉H₁₁O₃S^(1-)

1-amino-5-methoxypyridinium 2,4,6-trimethylbenzenesulfonate

N-amino-5-propionyl-2-methylpyridinium mesitylene sulfonium

Refernces

• 1、 -. "THE USE OF N-(4-IODOBENZOYLAMINO)-5-ETHYL-1,2,3,6-TETRAHYDROPYRIDINE AS A TREATMENT FOR CANCER". Paragraph 0023. . Retrieved 2020/04/24.
• 2、 Li, Yanan,Wang, Bin,Chang, Pei,Hu, Jianjian,Chen, Tao,Wang, Yinglei,Wang, Bozhou. "Novel catenated N6 energetic compounds based on substituted 1,2,4-triazoles: Synthesis, structures and properties". . p. 13755 - 13763. Retrieved 2018/04/25.