2,3-dihydro-1,4-ethanoquinoxaline

Base Information

• Chemical Name: 2,3-dihydro-1,4-ethanoquinoxaline
• CAS No.: 7140-45-6
• Molecular Formula: C10H12N2
• Molecular Weight: 160.219
• Mol file: 7140-45-6.mol

Synonyms:2,3-Dihydro-1,4-ethanoquinoxaline;Benzo[b]-1,4-diazabicyclo[2.2.2]octane;

Chemical Property of 2,3-dihydro-1,4-ethanoquinoxaline

Chemical Property:

• Vapor Pressure: 0.00348mmHg at 25°C
• Refractive Index: 1.67
• Boiling Point: 281.8 °C at 760 mmHg
• Flash Point: 119.4 °C
• Density: 1.22 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydro-1,4-ethanoquinoxaline

There total 3 articles about 2,3-dihydro-1,4-ethanoquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

1-(2-hydroxyethyl)-benzo-1-azonium-4-azabicyclo<2.2.2>octene chloride (145079-37-4) → C24H32N4O2 + Benzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene (7140-45-6)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; Heating;

DOI:10.1007/BF00531326

Reference yield:

N-(β-bromoethyl)-1,2,3,4-tetrahydroquinoxaline (75398-72-0) → N-(β-hydroxyethyl)-1,2,3,4-tetrahydroquinoxaline (75398-68-4) + Benzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene (7140-45-6)

Guidance literature:

With hydrogen bromide; at 100 ℃; for 15h; Equilibrium constant; Product distribution; other concentration of HBr, various reagents (LiBr, H₂SO₄, HClO₄, polyphosphoric acid), various time;

DOI:10.1007/BF00553710

Reference yield:

→ Benzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene (7140-45-6)

Guidance literature:

/BRN= 120809/ 6-H, Ethylenbromid, Na2CO3;

DOI:10.1021/jo00407a015

upstream raw materials:

N-(β-bromoethyl)-1,2,3,4-tetrahydroquinoxaline

1-(2-hydroxyethyl)-benzo-1-azonium-4-azabicyclo<2.2.2>octene chloride

Downstream raw materials:

1-(β-bromoethyl)-4-ethoxycarbonyl-1,2,3,4-tetrahydroquinoxaline

N-(β-bromoethyl)-1,2,3,4-tetrahydroquinoxaline

N-(β-hydroxyethyl)-1,2,3,4-tetrahydroquinoxaline

3',6'-Bis(trimethylsilyl)benzo<1',2'-b>-1,4-diazabicyclo<2.2.2>octene

Refernces

• 1、 Shishkin, G. V.,Gall, A. A.. "DIAZABICYCLOALKANES WITH NITROGEN ATOMS IN THE NODAL POSITIONS. 4. INTRAMOLECULAR CYCLIZATION OF N-(β-X-ETHYL)-1,2,3,4-TETRAHYDROQUINOXALINES AND BEHAVIOR OF BENZO-1,4-DIAZABICYCLOOCTENES IN ACIDIC MEDIA". . p. 648 - 653. Retrieved 2007/10/02.