Technology Process of Shihunine
There total 13 articles about Shihunine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / CHCl3 / Ambient temperature
2: 67 percent / sodium hydroxide / methanol; H2O / 8 h / Ambient temperature
3: 68 percent / methanol; H2O / 2 h / 150 °C / sealed tube
4: 50 percent / methanol; H2O / 12 h / 180 °C / sealed tube
5: 48percent HBr / Heating
With
sodium hydroxide; hydrogen bromide;
In
methanol; chloroform; water;
DOI:10.1016/S0040-4020(01)82029-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / sodium hydroxide / methanol; H2O / 8 h / Ambient temperature
2: 68 percent / methanol; H2O / 2 h / 150 °C / sealed tube
3: 50 percent / methanol; H2O / 12 h / 180 °C / sealed tube
4: 48percent HBr / Heating
With
sodium hydroxide; hydrogen bromide;
In
methanol; water;
DOI:10.1016/S0040-4020(01)82029-9