2-Aminocarbazole

Base Information

• Chemical Name: 2-Aminocarbazole
• CAS No.: 4539-51-9
• Molecular Formula: C12H10N2
• Molecular Weight: 182.225
• Hs Code.: 2933990090
• NSC Number: 171107
• UNII: 222CW4U2Q4
• DSSTox Substance ID: DTXSID20196494
• Nikkaji Number: J83.263D
• Wikidata: Q27253599
• Mol file: 4539-51-9.mol

Synonyms:2-Aminocarbazole;9H-Carbazol-2-amine;4539-51-9;CCRIS 6503;Carbazole, 2-amino-;BRN 0135910;UNII-222CW4U2Q4;222CW4U2Q4;NSC-171107;5-22-10-00513 (Beilstein Handbook Reference);NSC171107;Nc1ccc2c(c1)Nc3ccccc23;9H-Carbazol-2-amine (9CI);SCHEMBL1181826;DTXSID20196494;AKOS006278478;NSC 171107;LS-51677;FT-0719522;Q27253599

Chemical Property of 2-Aminocarbazole

Chemical Property:

• Vapor Pressure: 5.75E-08mmHg at 25°C
• Melting Point: 238-239 °C
• Refractive Index: 1.827
• Boiling Point: 440.8 °C at 760 mmHg
• PKA: 17.34±0.30(Predicted)
• Flash Point: 250.6 °C
• PSA: 41.81000
• Density: 1.317 g/cm³
• LogP: 3.48450
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 182.084398327
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

99% ^*data from raw suppliers

9H-CARBAZOL-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=C(C=C3)N

Technology Process of 2-Aminocarbazole

There total 30 articles about 2-Aminocarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-acetylcarbazole (23592-74-7) → 2-aminocarbazole (4539-51-9)

Guidance literature:

With methanol; O-benzenesulfonyl-acetohydroxamic acid ethyl ester; toluene-4-sulfonic acid; at 23 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00807

Reference yield: 78.0%

2-acetylamino-9-acetylcarbazole (77229-05-1) → 2-aminocarbazole (4539-51-9)

Guidance literature:

With hydrogenchloride; In acetic acid; for 2.5h; Heating;

DOI:10.1016/0040-4020(80)88027-6

Reference yield: 75.0%

acetyl-9 amino-2 carbazole (86439-46-5) → 2-aminocarbazole (4539-51-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

DOI:10.1248/cpb.31.45

upstream raw materials:

2-nitrocarbazole

2,4'-diaminobiphenyl

2,9-diacetylcarbazole oxime

2-acetylamino-9-acetylcarbazole

Downstream raw materials:

N-(9H-carbazol-2-yl)acetamide

9H-carbazole-2-carbonitrile

2-chloro-9H-carbazole

Refernces

• 1、 -. "COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE". Paragraph 0168. . Retrieved 2020/11/12.
• 2、 Qiu, Zihang,Lv, Leiyang,Li, Jianbin,Li, Chen-Chen,Li, Chao-Jun. "Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium". . p. 4775 - 4781. Retrieved 2019/05/16.