1-Phenylcyclopentylamine

Base Information

• Chemical Name: 1-Phenylcyclopentylamine
• CAS No.: 17380-74-4
• Molecular Formula: C11 H15 N
• Molecular Weight: 161.247
• Hs Code.: 2921499090
• Mol file: 17380-74-4.mol

Synonyms:Cyclopentylamine,1-phenyl- (7CI,8CI);1-Phenylcyclopentylamine;

Chemical Property of 1-Phenylcyclopentylamine

Chemical Property:

• Vapor Pressure: 0.0185mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 253.2 °C at 760 mmHg
• PKA: 9.63±0.20(Predicted)
• Flash Point: 110 °C
• PSA: 26.02000
• Density: 1.014g/cm³
• LogP: 3.11490
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Phenylcyclopentylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenylcyclopentylamine

There total 17 articles about 1-Phenylcyclopentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-phenyl-1-cyclopentanecarboxylic acid (77-55-4) → 1-phenylcyclopentylamine (17380-74-4)

Guidance literature:

1-phenyl-1-cyclopentanecarboxylic acid; With chloroformic acid ethyl ester; triethylamine; In water; acetone; at 0 ℃; for 0.5h;

With sodium azide; In water; acetone; at 0 ℃; for 1h;

With hydrogenchloride; tert-butyl alcohol; more than 3 stages;

Reference yield: 61.0%

1-phenyl-1-cyclopentanecarboxylic acid (77-55-4) + 2-chloroethyl formate (1487-43-0) → 1-phenylcyclopentylamine (17380-74-4)

Guidance literature:

1-phenyl-1-cyclopentanecarboxylic acid; 2-chloroethyl formate; In water; acetone; at 0 ℃; for 0.5h;

With sodium azide; In H₂₀; at 0 ℃; for 1h;

With hydrogenchloride; tert-butyl alcohol; more than 3 stages;

Reference yield: 40.0%

1-(1-azidocyclopentyl)benzene (66021-70-3) → 1-phenylcyclopentylamine (17380-74-4)

Guidance literature:

With Raney nickel; In isopropyl alcohol; at 60 - 70 ℃;

DOI:10.15227/orgsyn.060.0104

upstream raw materials:

1-phenylcyclopentanol

1-phenylcyclopentanecarboxylic acid chloride

Methyl-(1-phenylcyclopentyl)-carbamat

1-(1-azidocyclopentyl)benzene

Downstream raw materials:

[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-(1-phenyl-cyclopentyl)-amine

(1-Phenyl-cyclopentyl)-[1-phenyl-meth-(E)-ylidene]-amine

2-(1-Phenyl-cyclopentylamino)-ethanol

Refernces

• 1、 Torrente, Esther,Parodi, Chiara,Ercolani, Luisa,De Mei, Claudia,Ferrari, Alessio,Scarpelli, Rita,Grimaldi, Benedetto. "Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy". . p. 5900 - 5915. Retrieved 2015/08/24.
• 2、 Tagad, Harichandra D.,Hamada, Yoshio,Nguyen, Jeffrey-Tri,Hidaka, Koushi,Hamada, Takashi,Sohma, Youhei,Kimura, Tooru,Kiso, Yoshiaki. "Structure-guided design and synthesis of P1′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors". . p. 5238 - 5246. Retrieved 2011/10/08.