1,2,6-Trimethylpiperidine

Base Information

• Chemical Name: 1,2,6-Trimethylpiperidine
• CAS No.: 4733-73-7
• Molecular Formula: C8H17N
• Molecular Weight: 127.2273
• NSC Number: 100163
• DSSTox Substance ID: DTXSID60902915
• Nikkaji Number: J47.435E
• Mol file: 4733-73-7.mol

Synonyms:1,2,6-Trimethylpiperidine;Piperidine, 1,2,6-trimethyl-;Piperidine, 1,2,6-trimethyl-, cis-;669-81-8;cis-1,2,6-Trimethylpiperidine;2439-13-6;NSC100163;BRN 0079892;1,6-Trimethylpiperidine;NoName_3491;Piperidine,2,6-trimethyl-;NCIOpen2_002141;SCHEMBL1776811;DTXSID60902915;COSHJOZVKGAYBP-UHFFFAOYSA-N;NSC-100163

Chemical Property of 1,2,6-Trimethylpiperidine

Chemical Property:

• Vapor Pressure: 8.07mmHg at 25°C
• Boiling Point: 134.5°Cat760mmHg
• Flash Point: 28.5°C
• PSA: 12.03000
• Density: 0.807g/cm³
• LogP: 2.25580
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 127.136099547
• Heavy Atom Count: 9
• Complexity: 80.6

Purity/Quality:

95% ^*data from raw suppliers

2,2,6-TRIMETHYLPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCCC(N1C)C

Technology Process of 1,2,6-Trimethylpiperidine

There total 3 articles about 1,2,6-Trimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,2,6-trimethyl-2,3,4,5-tetrahydropyridine (112269-97-3) → 2,2,6-trimethylpiperidine (4733-73-7)

Guidance literature:

With hydrogen; nickel; at 80 ℃; under 76000.1 Torr;

Reference yield:

→ 2,2,6-trimethylpiperidine (4733-73-7)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol;

DOI:10.1021/ja01577a029

Reference yield:

4-bromo-2,2,6-trimethyl-piperidine → 2,2,6-trimethylpiperidine (4733-73-7)

Guidance literature:

With acetic acid; zinc;

upstream raw materials:

2,2,6-trimethyl-2,3,4,5-tetrahydropyridine

Refernces

• 1、 Dneprovskii, A. S.,Mil'tsov, S. A.. "MECHANISMS OF FREE-RADICAL REACTIONS. XXV. REACTIVITY OF N-CHLORO-2,2,6,6-TETRAMETHYLPIPERIDINE IN FREE-RADICAL CHLORINATION OF ALIPHATIC COMPOUNDS". . p. 1836 - 1840. Retrieved 2007/10/02.