Atropine, sulfate (2:1)

Base Information Edit

Chemical Name:Atropine, sulfate (2:1)
CAS No.:2472-17-5
Molecular Formula:C₁₇H₂₃NO₃*H₂O₄S
Molecular Weight:387.454
Hs Code.:
European Community (EC) Number:200-235-0
NSC Number:755889,26671
DSSTox Substance ID:DTXSID30947656
NCI Thesaurus Code:C2744,C74575
RXCUI:1225,153971
ChEMBL ID:CHEMBL1396281
Mol file:2472-17-5.mol

Synonyms:Anhydrous, Atropine Sulfate;AtroPen;Atropin Augen?l;Atropine;Atropine Sulfate;Atropine Sulfate Anhydrous;Atropinol;Augen?l, Atropin;Sulfate Anhydrous, Atropine;Sulfate, Atropine

Suppliers and Price of Atropine, sulfate (2:1)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Atropine, sulfate (2:1) Edit

Chemical Property:

Melting Point:118.5oC
Boiling Point:429.8°Cat760mmHg
Flash Point:213.7°C
PSA：132.75000
Density:g/cm³
LogP:2.29680
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:387.13517331
Heavy Atom Count:26
Complexity:434

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements:Poison by intrave"> ATROPINE and SULFATES. When heated to decomposition it emits very toxic fumes of NOx and SOx." target="_blank">Poison by intrave

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.OS(=O)(=O)O
Recent ClinicalTrials:Low-dose Atropine Eye Drops to Reduce Progression of Myopia in Children in the United Kingdom
Recent EU Clinical Trials:Investigator led, double-masked, multicenter, randomized clinical trial for the comparison of Atropine 0.5% versus Atropine 0.05% eye drops for the prevention of myopia progression in Dutch children.

Technology Process of Atropine, sulfate (2:1)

There total 12 articles about Atropine, sulfate (2:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 51-55-8
Atropine

: 55-48-1,300-40-3,620-61-1,1867-24-9,2472-17-5,2623-69-0,14844-27-0,5908-99-6
(1R,3r,5S)-3-tropoyloxytropanium sulfate

Guidance literature:: With sulfuric acid; In acetone;

Reference yield:

: 51-55-8
Atropine

: 5908-99-6,55-48-1,300-40-3,620-61-1,1867-24-9,2472-17-5,2623-69-0,14844-27-0
atropine sulfate

Guidance literature:: With sulfuric acid; In dichloromethane; water; acetone; at 29 - 42 ℃; for 3.5h;

Reference yield:

: 59216-85-2
α-formyl phenyl acetic acid

: 5908-99-6,55-48-1,300-40-3,620-61-1,1867-24-9,2472-17-5,2623-69-0,14844-27-0
atropine sulfate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / toluene / 5 h / 109 - 115 °C

2: sodium tetrahydroborate; methanol / dichloromethane / 4 h / 0 - 20 °C

3: sulfuric acid / water; dichloromethane; acetone / 3.5 h / 29 - 42 °C

With methanol; sodium tetrahydroborate; sulfuric acid; sodium methylate; In dichloromethane; water; acetone; toluene;