2-Ethoxy-4-(methoxymethyl)phenol

Base Information

• Chemical Name: 2-Ethoxy-4-(methoxymethyl)phenol
• CAS No.: 5595-79-9
• Molecular Formula: C10H14 O3
• Molecular Weight: 182.219
• European Community (EC) Number: 447-640-0,611-336-8
• UNII: 7QHC87YPG8
• DSSTox Substance ID: DTXSID6074918
• Nikkaji Number: J2.400.968H
• Wikidata: Q82003041
• Metabolomics Workbench ID: 48172
• Mol file: 5595-79-9.mol

Synonyms:2-ethoxy-4-(methoxymethyl)phenol;5595-79-9;Methyl diantilis;Phenol, 2-ethoxy-4-(methoxymethyl)-;7QHC87YPG8;UNII-7QHC87YPG8;4-hydroxy-3-ethoxybenzyl methyl ether;2-ethoxy-4-methoxymethylphenol;SCHEMBL1472537;DTXSID6074918;CHEBI:179564;FNEWGEWRECZWQM-UHFFFAOYSA-N;Fenol, 2-etoxi-4-(metoximetil)-;2-Ethoxy-4-(methoxymethyl)-Phenol;p-Cresol, 2-ethoxy-alpha-methoxy-;2-Ethoxy-4-(methoxymethyl)phenol, 9CI

Chemical Property of 2-Ethoxy-4-(methoxymethyl)phenol

Chemical Property:

• Vapor Pressure: 0.00308mmHg at 25°C
• Boiling Point: 275.2°Cat760mmHg
• PKA: 10.03±0.31(Predicted)
• Flash Point: 120.2°C
• Density: 1.087g/cm³
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 138

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=CC(=C1)COC)O

Technology Process of 2-Ethoxy-4-(methoxymethyl)phenol

There total 4 articles about 2-Ethoxy-4-(methoxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3-ethoxy-4-hydroxy-benzyl alcohol (4912-58-7) → 2-ethoxy-4-(methoxymethyl)phenol (5595-79-9)

Guidance literature:

With Sn-Beta zeolite; at 65 ℃; for 24h;

DOI:10.1002/anie.200604018

Reference yield: 97.0%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) + methanol (67-56-1) → 2-ethoxy-4-(methoxymethyl)phenol (5595-79-9)

Guidance literature:

With hydrogen; at 60 ℃; for 19h; under 15001.5 Torr; Industrial scale;

Reference yield: 88.0%

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) + trimethyl orthoformate (149-73-5) → 2-ethoxy-4-(methoxymethyl)phenol (5595-79-9)

Guidance literature:

With C₁₈H₄BCl₃F₈; hydrogen; In tetrahydrofuran; at 55 ℃; for 16h; under 15001.5 Torr;

DOI:10.1002/anie.201700231

upstream raw materials:

methanol

3-ethoxy-4-hydroxy-benzyl alcohol

4-hydroxy-3-ethoxybenzaldehyde

trimethyl orthoformate

Refernces

• 1、 -. "Technology for preparing vanillyl alcohol ether by using one step method". Paragraph 0031; 0032. . Retrieved 2017/03/18.