4-METHYLPHENYLACETONE

Base Information

• Chemical Name: 4-METHYLPHENYLACETONE
• CAS No.: 2096-86-8
• Molecular Formula: C10H12 O
• Molecular Weight: 148.205
• Hs Code.: 2914399090
• Mol file: 2096-86-8.mol

Synonyms:2-Propanone,1-p-tolyl- (8CI); 2-Propanone, p-tolyl- (7CI); (4-Methylphenyl)acetone;(p-Methylphenyl)acetone; 1-(p-Tolyl)-2-propanone; Methyl 4-methylbenzyl ketone;NSC 165796; p-Tolylacetone

Chemical Property of 4-METHYLPHENYLACETONE

Chemical Property:

• Appearance/Colour: clear light yellow liquid
• Vapor Pressure: 0.0982mmHg at 25°C
• Refractive Index: 1.5130 (estimate)
• Boiling Point: 223.1°Cat760mmHg
• Flash Point: 97.1°C
• PSA: 17.07000
• Density: 0.974g/cm³
• LogP: 2.12650
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Methylphenylacetone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methylphenylacetone is a useful compound in organic synthesis.

Technology Process of 4-METHYLPHENYLACETONE

There total 77 articles about 4-METHYLPHENYLACETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

para-chlorotoluene (106-43-4) + acetone (67-64-1) → p-Tolylaceton (2096-86-8)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 2-methoxy-6-(N-methyl-N-phenyl-amino)phenyl(dicyclohexyl)phosphine; caesium carbonate; at 90 ℃; for 52.5h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201300207

Reference yield: 94.0%

p-allyltoluene (3333-13-9) → p-Tolylaceton (2096-86-8)

Guidance literature:

With iron(III) sulfate; palladium(II) trifluoroacetate; sodium 2,2,2-trifluoroacetate; In water; acetonitrile; at 30 ℃; Inert atmosphere; Darkness;

DOI:10.1002/adsc.201900179

Reference yield: 92.0%

1-(2-Iodo-1-methoxy-1-methyl-ethyl)-4-methyl-benzene (98236-11-4) → p-Tolylaceton (2096-86-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(00)98579-4

upstream raw materials:

2,3-epoxy-2-methyl-3-p-tolyl-propionic acid ethyl ester

1-(p-methylphenyl)-1-cyanoacetone

chloroacetone

para-methylphenylmagnesium bromide

Downstream raw materials:

2-methyl-1-(4-methylphenyl)propan-2-ol

1,3-Dibromo-1-p-tolyl-propan-2-one

1-(hydroxyimino)-1-(p-tolyl)propan-2-one

2-(1-Phenylsulfanyl-cyclopropyl)-1-p-tolyl-propan-2-ol

Refernces

• 1、 Leo,Orcajo,Briones,Martínez,Calleja. "Direct α-arylation of ketones efficiently catalyzed by Cu-MOF-74". . p. 251 - 257. Retrieved 2020.
• 2、 Doppiu, Angelino,Goo?en, Lukas J.,Hu, Zhiyong,Pirkl, Nico,Sivendran, Nardana. "Halogen-Bridged Methylnaphthyl Palladium Dimers as Versatile Catalyst Precursors in Coupling Reactions". supporting information. p. 25151 - 25160. Retrieved 2021/10/19.
• 3、 -. "Aryl C-F bond functionalization preparation method". Paragraph 0052; 0089-0093; 0103-0107. . Retrieved 2021/09/29.