9-HYDROXY-PHENALEN-1-ONE

Base Information

• Chemical Name: 9-HYDROXY-PHENALEN-1-ONE
• CAS No.: 7465-58-9
• Molecular Formula: C13H8O2
• Molecular Weight: 196.205
• Hs Code.: 2914400090
• Mol file: 7465-58-9.mol

Synonyms:9-hydroxy-1H-phenalen-1-one;1H-Phenalen-1-one,9-hydroxy;9-Hydroxy-1-oxophenalene;9-hydroxyophenalenone;9-HYDROXY-PHENALEN-1-ONE;9-hydroxyphenal-1-one;9-Hydroxyphenalenone;

Chemical Property of 9-HYDROXY-PHENALEN-1-ONE

Chemical Property:

• Vapor Pressure: 2.29E-07mmHg at 25°C
• Boiling Point: 407.3°Cat760mmHg
• Flash Point: 173.9°C
• PSA: 37.30000
• Density: 1.427g/cm³
• LogP: 2.75490

Purity/Quality:

99% ^*data from raw suppliers

9-HYDROXY-1H-PHENALEN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-HYDROXY-PHENALEN-1-ONE

There total 13 articles about 9-HYDROXY-PHENALEN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

phenaleno<1,9-bc>furan (57984-09-5) → 9-hydroxy-1-oxophenalene (7465-58-9)

Guidance literature:

With oxygen; In tetrahydrofuran; at 20 ℃; for 0.333333h; Irradiation; Rose Bengal, sens.;

Reference yield: 60.0%

2-Methoxynaphthalene (93-04-9) + Cinnamoyl chloride (102-92-1,17082-09-6) → 9-hydroxy-1-oxophenalene (7465-58-9)

Guidance literature:

2-Methoxynaphthalene; Cinnamoyl chloride; With aluminum (III) chloride; In dichloromethane; at 0 ℃; Inert atmosphere;

In dichloromethane; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/acsmedchemlett.1c00284

Reference yield:

2-Methoxynaphthalene (93-04-9) + cinnamoyl chloride (102-92-1,17082-09-6) → 9-hydroxy-1-oxophenalene (7465-58-9)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; 1) ca. 0 deg C to room temperature, ca. 1 h, 2) reflux, 3 h;

DOI:10.1021/jo00335a060

upstream raw materials:

2,3-dihydronaphtho[2,1-b]pyran-1-one

1-acetyl-2-ethoxynaphthalene

formic acid ethyl ester

2-Methoxynaphthalene

Downstream raw materials:

benzene-1,2,3-tricarboxlic acid

9-methoxy-1H-phenalen-1-one

C₃₇H₂₃N₃O₄Ru

9-amino-1-phenaleneimine

Refernces

• 1、 Kovacs, Attila,Izvekov, Vladislav,Zauer, Karoly,Ohta, Koji. "Strong intramolecular hydrogen bonding and molecular vibrations of 9-hydroxyphenalen-1-one". . p. 5000 - 5009. Retrieved 2001.
• 2、 Kaye, Esther G.,Kailass, Karishma,Sadovski, Oleg,Beharry, Andrew A.. "A Green-Absorbing, Red-Fluorescent Phenalenone-Based Photosensitizer as a Theranostic Agent for Photodynamic Therapy". supporting information. p. 1295 - 1301. Retrieved 2021/08/01.
• 3、 Dutta, Pradip Kumar,Sharma, Rupali,Kumari, Smita,Dubey, Ravindra Dhar,Sarkar, Sujit,Paulraj, Justin,Vijaykumar, Gonela,Pandey, Manoj,Sravanti,Samarla, Mallik,Das, Hari Sankar,Yashpal,Heeralal,Goyal, Ravinder,Gupta, Nimish,Mandal, Swadhin K.,Sengupta, Aniruddha,Sarkar, Arindam. "A safe and efficacious Pt(ii) anticancer prodrug: Design, synthesis,: In vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition". supporting information. p. 1718 - 1721. Retrieved 2019/02/12.