1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXAMIDE

Base Information

• Chemical Name: 1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXAMIDE
• CAS No.: 7032-11-3
• Molecular Formula: C6H10 N2 O
• Molecular Weight: 126.158
• Hs Code.: 2933399990
• Mol file: 7032-11-3.mol

Synonyms:Nicotinamide,1,4,5,6-tetrahydro- (7CI,8CI); NSC 93656

Chemical Property of 1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXAMIDE

Chemical Property:

• Vapor Pressure: 2.4E-05mmHg at 25°C
• Melting Point: 203 °C
• Boiling Point: 359.3°C at 760 mmHg
• Flash Point: 171.1°C
• PSA: 55.12000
• Density: 1.27g/cm³
• LogP: 0.76810

Purity/Quality:

99%, ^*data from raw suppliers

1,4,5,6-Tetrahydro-3-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXAMIDE

There total 3 articles about 1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

nicotinamide (98-92-0,1255150-40-3) → nipecotamide (4138-26-5,168749-30-2) + 1,4,5,6-tetrahydropyridine-3-carboxamide (7032-11-3)

Guidance literature:

With palladium on carbon type-K; hydrogen; In methanol; at 40 ℃; for 21h; under 750.075 Torr; Temperature; Pressure; Autoclave;

DOI:10.1021/acs.oprd.0c00544

Reference yield: 68.0%

nicotinamide (98-92-0,1255150-40-3) → 1,4,5,6-tetrahydropyridine-3-carboxamide (7032-11-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 45 ℃; for 14h; under 750.075 Torr; Autoclave;

Reference yield:

→ 1,4,5,6-tetrahydropyridine-3-carboxamide (7032-11-3)

Guidance literature:

Nicotinsaeureamid, H2, Pd/C;

DOI:10.1021/jo01266a054

upstream raw materials:

nicotinamide

Downstream raw materials:

(R)-piperidine-3-carboxamide

(S)-piperidine-3-carboxamide

alogliptin

Alogliptin benzoate

Refernces

• 1、 -. "PROCESS FOR PRODUCING HETEROCYCLIC COMPOUND". Paragraph 0274-0280. . Retrieved 2017/04/11.