2-amino-4-(S-butylsulfonimidoyl)butanoate

Base Information Edit

Chemical Name:2-amino-4-(S-butylsulfonimidoyl)butanoate
CAS No.:83730-53-4
Molecular Formula:C8H18 N2 O3 S
Molecular Weight:222.309
Hs Code.:29309090
Mol file:83730-53-4.mol

Synonyms:2-amino-4-(S-butylsulfonimidoyl)butanoate

Suppliers and Price of 2-amino-4-(S-butylsulfonimidoyl)butanoate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
L-Buthionine-[S,R]-Sulfoximine
1g
$ 523.00

TRC
L-Buthionine-(S,R)-sulfoximine
5g
$ 815.00

TRC
L-Buthionine-(S,R)-sulfoximine
250mg
$ 70.00

Tocris
L-Buthioninesulfoximine ≥98%(HPLC)
100
$ 109.00

Sigma-Aldrich
L-Buthionine-sulfoximine ≥97% (TLC)
5g
$ 1210.00

Sigma-Aldrich
L-Buthionine-sulfoximine ≥97% (TLC)
500mg
$ 222.00

Sigma-Aldrich
L-ButhionineSulfoximine-CAS83730-53-4-Calbiochem
100 mg
$ 118.00

Sigma-Aldrich
L-Buthionine-sulfoximine ≥97% (TLC)
1g
$ 348.00

Medical Isotopes, Inc.
L-Buthionine-(S,R)-sulfoximine
250 mg
$ 290.00

Crysdot
(2S)-2-Amino-4-(butylsulfonimidoyl)butanoicacid 95+%
10g
$ 1380.00

Total 34 raw suppliers

Chemical Property of 2-amino-4-(S-butylsulfonimidoyl)butanoate Edit

Chemical Property:

Appearance/Colour:white fine powder
Vapor Pressure:6.64E-07mmHg at 25°C
Melting Point:224-228 °C (dec.)
Refractive Index:1.6300 (estimate)
Boiling Point:382.3 °C at 760 mmHg
Flash Point:185 °C
PSA：112.62000
Density:1.29 g/cm³
LogP:2.30100
Storage Temp.:2-8°C
Solubility.:H2O: 50 mg/mL, clear, colorless to faintly yellow
XLogP3:-0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:222.10381361
Heavy Atom Count:14
Complexity:279

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

L-Buthionine-[S,R]-Sulfoximine ^*data from reagent suppliers

Safty Information:

Pictogram(s): A reproductive hazard.
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCS(=N)(=O)CCC(C(=O)[O-])[NH3+]
Isomeric SMILES:CCCCS(=N)(=O)CC[C@@H](C(=O)[O-])[NH3+]
Description L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.
Uses A potent and specific inhibitor of alpha-glutamylcysteine synthetase inhibitor of gamma-glutamylcysteine synthetase Buthionine sulfoximine (BSO) is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of BSO leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, BSO has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors. L-Buthionine-(S,R)-sulfoximine is a potent and specific inhibitor of alpha-glutamylcysteine synthetase.

Technology Process of 2-amino-4-(S-butylsulfonimidoyl)butanoate

There total 2 articles about 2-amino-4-(S-butylsulfonimidoyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%