3-ACETAMIDOCOUMARIN

Base Information

• Chemical Name: 3-ACETAMIDOCOUMARIN
• CAS No.: 779-30-6
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.197
• Hs Code.: 2932209090
• Mol file: 779-30-6.mol

Synonyms:Coumarin,3-acetamido-(6CI,7CI,8CI);3-(Acetylamino)coumarin;3-Acetamidocoumarin;NSC65873;

Chemical Property of 3-ACETAMIDOCOUMARIN

Chemical Property:

• Appearance/Colour: LIGHT YELLOW AMORPHOUS POWDER
• Vapor Pressure: 1.89E-09mmHg at 25°C
• Melting Point: 205-207 °C(lit.)
• Refractive Index: 1.604
• Boiling Point: 482 °C at 760 mmHg
• Flash Point: 245.3 °C
• PSA: 59.31000
• Density: 1.31 g/cm³
• LogP: 1.82440

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Acetamidocoumarin ^*data from reagent suppliers

Safty Information:

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-ACETAMIDOCOUMARIN is a 3-substituted couramin derivative with antioxidant activity. It is used as a matrix in MALDI TOF-MS analysis of polyethylene glycol samples.

Technology Process of 3-ACETAMIDOCOUMARIN

There total 9 articles about 3-ACETAMIDOCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-acetylcoumarin (3949-36-8) → 3-acetamidocoumarin (779-30-6)

Guidance literature:

With hydroxylamine hydrochloride; water; Thiamine hydrochloride; In 1,4-dioxane; at 90 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2020.151859

Reference yield: 85.0%

salicylaldehyde (90-02-8) + N-acetylglycine (543-24-8) → 3-acetamidocoumarin (779-30-6)

Guidance literature:

With piperidine; acetic anhydride; at 130 ℃; for 8h;

DOI:10.3390/molecules16086969

Reference yield: 60.0%

acetamide (60-35-5) + 3-bromo-2H-chromen-2-one (939-18-4) → 3-acetamidocoumarin (779-30-6)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1016/j.tetlet.2007.07.166

upstream raw materials:

2-methyl-4H-oxazol-5-one

salicylaldehyde

N-acetylglycine

3-(1-hydroxyimino-ethyl)-coumarin

Downstream raw materials:

aminocoumarine

Chromannedione-2,3

3-(2'-hydroxyphenyl)-2-hydroxypropanoic acid

2-hydroxy-phenylalanine

Refernces

• 1、 Basude, Manohar,Gudipudi, Gopinath,Gundla, Rambabu,Kumar Pasala, Vijay,Nareshkumar, Devasani,Sankeshi, Venu,Srinivas, Burra,Yadaiah Goud, E.,singh Jadav, Surendar. "Design, synthesis and biological evaluation of selective hybrid coumarin-thiazolidinedione aldose reductase-II inhibitors as potential antidiabetics". . . Retrieved 2021/06/15.
• 2、 Bai, Renren,Gu, Jinping,Guo, Jianan,Jiang, Xiaoying,Lv, Yangjing,Mi, Zhisheng,Shi, Yuan,Xie, Yuanyuan,Yao, Chuansheng,Zhang, Changjun,Zhou, Tao. "Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity". . . Retrieved 2020/05/22.