Lycorine hydrochloride

Base Information

• Chemical Name: Lycorine hydrochloride
• CAS No.: 2188-68-3
• Molecular Formula: C16H17NO4^.HCl
• Molecular Weight: 323.776
• European Community (EC) Number: 633-615-3
• UNII: 58F70VH0HS
• DSSTox Substance ID: DTXSID80944478
• Wikidata: Q27261592
• ChEMBL ID: CHEMBL2092590
• Mol file: 2188-68-3.mol

Synonyms:Lycorine hydrochloride;2188-68-3;Lycorine chloride;Lycorine HCl;Licorin hydrochloride;Lycorine (hydrochloride);58F70VH0HS;(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride;(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride;Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride;Galanthan-1,2-diol, 3-12-didehydro-9,10-(methylenebis(oxy))-, hydrochloride, (1-alpha,2-beta)-;Lycorine-chloride;Licorine hydrochloride;Amarylline hydrochloride;Narcissine hydrochloride;Galanthidine hydrochloride;UNII-58F70VH0HS;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-;SCHEMBL8437600;CHEMBL2092590;DTXSID80944478;LYCORINE HYDROCHLORIDE [MI];HY-N0289;MFCD00243111;s3800;AKOS030228351;LYCORINE HYDROCHLORIDE, (+)-;CCG-267737;CS-5954;AC-34971;BS-42350;LS-88399;Lycorine hydrochloride, >=98% (TLC), powder;Q-100273;Q27261592;(1S,2S,12BS,12CS)-2,4,5,7,12B,12C-HEXAHYDRO-1H-(1,3)DIOXOLO(4,5-J)PYRROLO(3,2,1-DE)PHENANTHRIDINE-1,2-DIOL HYDROCHLORIDE;(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diolhydrochloride;1H-(1,3)DIOXOLO(4,5-J)PYRROLO(3,2,1-DE)PHENANTHRIDINE-1,2-DIOL, 2,4,5,7,12B,12C-HEXAHYDRO-, HYDROCHLORIDE (1:1), (1S,2S,12BS,12CS)-;2,4,5,7,12b,12c-Hexahydro-1H,10H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol--hydrogen chloride (1/1)

Chemical Property of Lycorine hydrochloride

Chemical Property:

• Appearance/Colour: fine crystal powder.
• Vapor Pressure: 6.37E-10mmHg at 25°C
• Melting Point: 210-212oC
• Boiling Point: 477.4 °C at 760 mmHg
• Flash Point: 242.5 °C
• PSA: 62.16000
• LogP: 0.68650
• Storage Temp.: 2-8°C
• Solubility.: Soluble in water (15 mg/ml)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 323.0924357
• Heavy Atom Count: 22
• Complexity: 481

Purity/Quality:

99% ^*data from raw suppliers

Lycorine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4.Cl
• Isomeric SMILES: C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4.Cl
• Description: Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5