N,N-Dicyclohexylacetamide

Base Information

• Chemical Name: N,N-Dicyclohexylacetamide
• CAS No.: 1563-91-3
• Molecular Formula: C14H25 N O
• Molecular Weight: 223.359
• Hs Code.: 2924299090
• Mol file: 1563-91-3.mol

Synonyms:N,N-Di-n-cyclohexylacetamide;N,N-Dicyclohexylacetamide; N-Acetyldicyclohexylamine; NSC 8318

Chemical Property of N,N-Dicyclohexylacetamide

Chemical Property:

• Vapor Pressure: 5.16E-05mmHg at 25°C
• Boiling Point: 348.1°Cat760mmHg
• Flash Point: 152°C
• PSA: 20.31000
• Density: 0.98g/cm³
• LogP: 3.50030

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Dicyclohexylacetamide

There total 6 articles about N,N-Dicyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-cyclohexyl-cyclohexanamine (101-83-7) + 1-ethoxyacetylene (927-80-0) → N,N-dicyclohexylacetamide (1563-91-3)

Guidance literature:

In toluene; at 180 ℃; for 0.166667h; Flow reactor;

DOI:10.1002/ejoc.201403603

Reference yield: 74.0%

N-Methyldicyclohexylamine (7560-83-0) + acetic anhydride (108-24-7) → N,N-dicyclohexylacetamide (1563-91-3)

Guidance literature:

With oxygen; copper diacetate; at 85 ℃; for 36h; Schlenk technique; Sealed tube;

DOI:10.1039/c5cc07454a

Reference yield:

dichloromethane (75-09-2) + carbon monoxide (201230-82-2) + N-cyclohexyl-cyclohexanamine (101-83-7) → N-Methyldicyclohexylamine (7560-83-0) + N,N-dicyclohexylacetamide (1563-91-3)

Guidance literature:

Pd(PCy₃)2(dba); tricyclohexylphosphine; In toluene; at 180 ℃; for 2.5h; under 22501.8 Torr; Mechanism;

upstream raw materials:

Ketene

N-cyclohexyl-cyclohexanamine

dichloromethane

carbon monoxide

Downstream raw materials:

{ThBr₃(CH₃CON(C₆H₁₁)2)2((CH₂)4O)}⁽¹⁺⁾*Br^(1-)={ThBr₃(CH₃CON(C₆H₁₁)2)2((CH₂)4O)}Br

{ThBr₃(CH₃CON(C₆H₁₁)2)3}⁽¹⁺⁾*Br^(1-)={ThBr₃(CH₃CON(C₆H₁₁)2)3}Br

{ThBr₄(CH₃CON(C₆H₁₁)2)2}

tris(dicyclohexylacetamide)dichlorodiisothiocyanatothorium(IV)

Refernces

• 1、 Cheng, Hui-Cheng,Hou, Wen-Jun,Li, Zeng-Wen,Liu, Ming-Yu,Guan, Bing-Tao. "The copper-catalyzed aerobic oxidative amidation of tertiary amines". supporting information. p. 17596 - 17599. Retrieved 2015/12/08.
• 2、 Huser, Marc,Youinou, Marie-Therese,Osborn, John A.. "Aktivierung der C-Cl-Bindung: Katalytische Carbonylierung von Dichlormethan und Chlorbenzol". . p. 1427 - 1430. Retrieved 2007/10/02.