2-(3-Chlorophenyl)ethylamine

Base Information

• Chemical Name: 2-(3-Chlorophenyl)ethylamine
• CAS No.: 13078-79-0
• Molecular Formula: C8H10ClN
• Molecular Weight: 155.627
• Hs Code.: 29214990
• Mol file: 13078-79-0.mol

Synonyms:m-Chlorophenylethylamine;m-Chlorophenethylamine;Phenethylamine,m-chloro- (6CI,7CI,8CI);(2-(3-Chlorophenyl)ethyl)amine;2-(3-Chlorophenyl)ethanamine;2-(m-Chlorophenyl)ethylamine;3-Chlorobenzeneethanamine;3-Chlorophenethylamine;3-Chlorophenylethylamine;

Chemical Property of 2-(3-Chlorophenyl)ethylamine

Chemical Property:

• Appearance/Colour: clear light yellow liquid
• Vapor Pressure: 0.056mmHg at 25°C
• Refractive Index: n20/D 1.549(lit.)
• Boiling Point: 233.392 °C at 760 mmHg
• PKA: 9.65±0.10(Predicted)
• Flash Point: 107.5 °C
• PSA: 26.02000
• Density: 1.129 g/cm³
• LogP: 2.54150

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3-Chlorophenyl)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36/38
• Safety Statements: 26-37/39-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-(3-Chlorophenyl)ethylamine has been used as a reactant in the synthesis of novel Fyn inhibitors as agents against tauopathies and tumors.

Technology Process of 2-(3-Chlorophenyl)ethylamine

There total 12 articles about 2-(3-Chlorophenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-chloro-benzeneacetonitrile (1529-41-5) → 2-(3-chlorophenyl)ethylamine (13078-79-0)

Guidance literature:

With potassium borohydride; copper dichloride; In water; isopropyl alcohol; at 60 ℃; for 7h;

DOI:10.14233/ajchem.2015.18836

Reference yield: 41.0%

3-chloroβ-nitrostyrene (37888-03-2,3156-35-2) → 2-(3-chlorophenyl)ethylamine (13078-79-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

Reference yield:

3-Chlorostyrene (2039-85-2,26100-04-9) → 2-(3-chlorophenyl)ethylamine (13078-79-0)

Guidance literature:

With D-Glucose; ammonia; oxygen; In aq. phosphate buffer; at 30 ℃; for 24h; regioselective reaction; Green chemistry;

DOI:10.1021/acscatal.7b01464

upstream raw materials:

3-chlorohydrocinnamic acid

3-chloro-benzeneacetonitrile

3-chloroβ-nitrostyrene

1-Chloro-3-((Z)-2-nitro-vinyl)-benzene

Downstream raw materials:

N-(3-chlorophenethyl)formamide

1-indoline

N-<2-(3-chlorophenyl)ethyl>acetamide

(2R,3R,4S,5R)-2-{6-[2-(3-Chloro-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Refernces

• 1、 Betori, Rick C.,May, Catherine M.,Scheidt, Karl A.. "Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations". supporting information. p. 16490 - 16494. Retrieved 2019/11/03.
• 2、 Jiang, Han,Hu, Jialei,Xu, Xinliang,Zhou, Yifeng. "Preparation and characterization of primary amines by potassium borohydride-copper chloride system from nitriles". . p. 3564 - 3566. Retrieved 2015/12/30.