2,2,2-TRICHLORO-N,N-DIMETHYLACETAMIDE

Base Information

• Chemical Name: 2,2,2-TRICHLORO-N,N-DIMETHYLACETAMIDE
• CAS No.: 7291-33-0
• Molecular Formula: C₄H₆Cl₃NO
• Molecular Weight: 190.457
• Mol file: 7291-33-0.mol

Synonyms:2,2,2-Trichloro-N,N-dimethylacetamide;Dimethyltrichloroacetamide;N,N-Dimethyl-2,2,2-trichloroacetamide;N,N-Dimethyl-a,a,a-trichloroacetamide;N,N-Dimethyltrichloroacetamide;

Chemical Property of 2,2,2-TRICHLORO-N,N-DIMETHYLACETAMIDE

Chemical Property:

• Vapor Pressure: 0.698mmHg at 25°C
• Melting Point: 12°C
• Refractive Index: 1.495
• Boiling Point: 185.4 °C at 760 mmHg
• PKA: -1.52±0.70(Predicted)
• Flash Point: 65.9 °C
• PSA: 20.31000
• Density: 1.43 g/cm³
• LogP: 1.44480

Purity/Quality:

98%Min ^*data from raw suppliers

NN-Dimethyltrichloroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-TRICHLORO-N,N-DIMETHYLACETAMIDE

There total 7 articles about 2,2,2-TRICHLORO-N,N-DIMETHYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

dimethyl amine (124-40-3) + trifluoroacetyl chloride (76-02-8) → 2,2,2-trichloro-N,N-dimethylacetamide (7291-33-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/ejoc.202101235

Reference yield:

4-dimethylamino[(dimethylamino)methyl]benzene (51227-15-7) + trifluoroacetyl chloride (76-02-8) → 2,2,2-trichloro-N,N-dimethylacetamide (7291-33-0)

Guidance literature:

With trimethylamine; In diethyl ether; at -20 ℃;

Reference yield:

N,N-dimethylphosphoroamidic dichloride (677-43-0) + trichloroacetic acid (76-03-9) → 2,2,2-trichloro-N,N-dimethylacetamide (7291-33-0)

Guidance literature:

at 140 ℃;

upstream raw materials:

dimethyl amine

trifluoroacetyl chloride

N,N-dimethylphosphoroamidic dichloride

trichloroacetic acid

Downstream raw materials:

C₁₁H₁₂ClNO

1,1,2-Trichloro-2-(dimethylamino)ethen

Refernces

• 1、 Stilbs. "". . p. 2269,2271,2273. Retrieved 1973.
• 2、 LaPlanche Graham, Laurine. "Primary and Secondary Binding Sites for Lanthanide Shift Reagents with Amides. Differential Behavior of cis vs trans Amide Isomers with LSR". . p. 40 - 44. Retrieved 2007/10/02.